An in vitro study on curcumin delivery by nanomicelles for esophageal squamous cell carcinoma (KYSE-30)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HOSSEINI SARE; CHAMANI JAMSHIDKHAN; RAHIMI Hamidreza; Azmoodeh Navid; GHASEMI FAEZEH; Hassan Abadi Porya

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY Year:2018 | Volume:6 | Issue:2 Page(s): 137-143

Download Full-Text

View:

119

Download:

Cites:

Information Journal Paper

Title

An in vitro study on curcumin delivery by nanomicelles for esophageal squamous cell carcinoma (KYSE-30)

Author(s)

Keywords

Curcumin

Cyclin D1 gene

Drug resistance

KYSE-30 cells

Nano-Micelle

Abstract

Background: The incidence of esophageal squamous cell carcinoma (ESCC) is increasing, causing catastrophic health burdens on communities. Curcumin has shown promise as a therapeutic agent in the treatment of colon, colorectal, pancreatic, and esophageal cancers but it has very poor bioavailability. The application of nano-carriers as drug delivery systems increases Curcumin's bioavailability. Cyclin D1 is overexpressed in ESCC and Curcumin may change its expression. Methods: In this study, the effect of SinaCurcumin® , a novel Nano-Micelle product containing 80 mg Curcumin, on the growth of KYSE-30 cells and expression of cyclin D1, was investigated. Paclitaxel and Carboplatin served as reference drugs. Results: Nano-Curcumin increased cell cytotoxicity, decreased IC50, and down-regulated of cyclin D1. However, treatment of cells with nano-Curcumin might result in multiDrug resistance. Conclusions: Nano-Curcumin suppressed proliferation of KYSE-30 cells and expression of cyclin D1 although its use in combination with other chemotherapeutic agents requires further testing.

Cites

The effect of nanomicelle curcumin, sorafenib, and combination of the two on the cyclin D1 gene expression of the hepatocellular carcinoma cell line (HUH7)

References

No record.

Cite

APA: Copy

HOSSEINI, SARE, CHAMANI, JAMSHIDKHAN, RAHIMI, Hamidreza, Azmoodeh, Navid, GHASEMI, FAEZEH, & Hassan Abadi, Porya. (2018). An in vitro study on curcumin delivery by nanomicelles for esophageal squamous cell carcinoma (KYSE-30). REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 6(2), 137-143. SID. https://sid.ir/paper/343149/en

Vancouver: Copy

HOSSEINI SARE, CHAMANI JAMSHIDKHAN, RAHIMI Hamidreza, Azmoodeh Navid, GHASEMI FAEZEH, Hassan Abadi Porya. An in vitro study on curcumin delivery by nanomicelles for esophageal squamous cell carcinoma (KYSE-30). REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2018;6(2):137-143. Available from: https://sid.ir/paper/343149/en

IEEE: Copy

SARE HOSSEINI, JAMSHIDKHAN CHAMANI, Hamidreza RAHIMI, Navid Azmoodeh, FAEZEH GHASEMI, and Porya Hassan Abadi, “An in vitro study on curcumin delivery by nanomicelles for esophageal squamous cell carcinoma (KYSE-30),” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 6, no. 2, pp. 137–143, 2018, [Online]. Available: https://sid.ir/paper/343149/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops