The Prevalence of VIM, IMP, and NDM-1 Metallo-beta-Lactamase Genes in Clinical Isolates of Klebsiella pneumoniae in Qom Province, Iran

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Sarem Marzieh; Saremi Leila; NAZARI RAZIEH; Feizy Fatemeh; VAFAEI SOMAYEH; LASHKARI ALI; SALTANATPOUR ZOHREH

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Journal: JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES Year:2020 | Volume:8 | Issue:1 Page(s): 34-39

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Title

The Prevalence of VIM, IMP, and NDM-1 Metallo-beta-Lactamase Genes in Clinical Isolates of Klebsiella pneumoniae in Qom Province, Iran

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Keywords

Klebsiella pneumonia

Metallo-beta-lactamase genes

Antibiotic resistance

PCR

Abstract

Introduction: An increase in the consumption of antibiotics has raised significant concerns over the treatment of Klebsiella pneumonia-infected patients. In this study, the resistance pattern of K. pneumoniae to antibiotics such as imipenem, meropenem, and ertapenem, as well as the frequency of Metallo-beta-lactamase (MBL) genes, namely VIM, IMP, and NDM-1 were investigated. Methods: Following the isolation of 200 K. pneumoniae isolates from 650 clinical samples, the Antibiotic resistance pattern of these isolates against different antibiotics was evaluated. The isolates resistant to imipenem, meropenem, and ertapenem were identified, and the presence of VIM, IMP, and NDM-1 genes was examined by using PCR methods. Results: The K. pneumoniae isolates exhibited different resistance patterns in response to various antibiotics. The frequency of VIM, IMP, and NDM-1 genes showed that 48 strains are resistant to imipenem, meropenem, and ertapenem in which 15. 6% was positive for IMP, 2. 42% for VIM, and 1. 92% positive for NDM-1 gene. The isolates showed the highest Antibiotic resistance to ampicillin (97. 5%) and the lowest to meropenem (5. 5%). Conclusion: Considering carbapenem antibiotics such as imipenem, meropenem, and ertapenem which are known to be among the most frequently used antibiotics for the treatment of K. pneumoniae infections and the involvement of MBL genes in this scenario, we aimed to screen and identify MBL genes responsible for the resistance of K. pneumoniae to imipenem, meropenem, and ertapenem.

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APA: Copy

Sarem, Marzieh, Saremi, Leila, NAZARI, RAZIEH, Feizy, Fatemeh, VAFAEI, SOMAYEH, LASHKARI, ALI, & SALTANATPOUR, ZOHREH. (2020). The Prevalence of VIM, IMP, and NDM-1 Metallo-beta-Lactamase Genes in Clinical Isolates of Klebsiella pneumoniae in Qom Province, Iran. JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES, 8(1), 34-39. SID. https://sid.ir/paper/343201/en

Vancouver: Copy

Sarem Marzieh, Saremi Leila, NAZARI RAZIEH, Feizy Fatemeh, VAFAEI SOMAYEH, LASHKARI ALI, SALTANATPOUR ZOHREH. The Prevalence of VIM, IMP, and NDM-1 Metallo-beta-Lactamase Genes in Clinical Isolates of Klebsiella pneumoniae in Qom Province, Iran. JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES[Internet]. 2020;8(1):34-39. Available from: https://sid.ir/paper/343201/en

IEEE: Copy

Marzieh Sarem, Leila Saremi, RAZIEH NAZARI, Fatemeh Feizy, SOMAYEH VAFAEI, ALI LASHKARI, and ZOHREH SALTANATPOUR, “The Prevalence of VIM, IMP, and NDM-1 Metallo-beta-Lactamase Genes in Clinical Isolates of Klebsiella pneumoniae in Qom Province, Iran,” JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES, vol. 8, no. 1, pp. 34–39, 2020, [Online]. Available: https://sid.ir/paper/343201/en

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