مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

130
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

58
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

Effect of Biarum carduchrum extract on brain tissue thiol level in rat model of 6-hydroxydopamine-induced Parkinson’ s disease

Pages

  136-140

Abstract

 Introduction: Parkinson’ s disease (PD) is developed due to the degeneration of dopaminergic neurons in the substantia nigra, which is widely associated with oxidative stress. The reduction of glutathione, as the most abundant and important tissue Thiol and an antioxidant defense agent, is one of the first biochemical events associated with PD, and therefore using antioxidants has a protective effect. In the present study, the effects of Biarum carduchrum extract on the Thiol levels in the tissues of the hippocampus, striatum, cortex, and cerebellum in PD were investigated. Methods: Wistar rats were randomly divided into 5 groups of 8 each. Control group was left without lesion. PD group received 8 μ g of neurotoxin-6-hydroxydopamine in the anteriormiddle-brain. Seven days after PD induction, groups 3-5 intragastrically received 100, 200, and 400 mg/mL of B. carduchrum extract, respectively, for 14 days. At completion of treatments, brain tissues were removed and their Thiol levels measured. Results: The levels of Thiol in cortex, cerebellum, hippocampus, and striatum were significantly lower in the rats with PD than the control group. In B. carduchrum extract-treated groups, the Thiol levels of cerebral cortex, cerebellum, hippocampus, and striatum tissues increased significantly compared to PD group. Conclusion: It seems that B. carduchrum extract leads to the functional regeneration of the nigro-striatal pathway through the mechanisms associated with its antioxidant properties.

Cites

References

  • No record.

    • Cite

    APA: Copy

    ZANGANEHNEJAD, ZAHRA, & SETORKI, MAHBUBEH. (2018). Effect of Biarum carduchrum extract on brain tissue thiol level in rat model of 6-hydroxydopamine-induced Parkinson’ s disease. JOURNAL OF HERBMED PHARMACOLOGY, 7(3), 136-140. SID. https://sid.ir/paper/343717/en

    Vancouver: Copy

    ZANGANEHNEJAD ZAHRA, SETORKI MAHBUBEH. Effect of Biarum carduchrum extract on brain tissue thiol level in rat model of 6-hydroxydopamine-induced Parkinson’ s disease. JOURNAL OF HERBMED PHARMACOLOGY[Internet]. 2018;7(3):136-140. Available from: https://sid.ir/paper/343717/en

    IEEE: Copy

    ZAHRA ZANGANEHNEJAD, and MAHBUBEH SETORKI, “Effect of Biarum carduchrum extract on brain tissue thiol level in rat model of 6-hydroxydopamine-induced Parkinson’ s disease,” JOURNAL OF HERBMED PHARMACOLOGY, vol. 7, no. 3, pp. 136–140, 2018, [Online]. Available: https://sid.ir/paper/343717/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button