DESIGN, SYNTHESIS, PHYSICOCHEMICAL AND IMMUNOLOGICAL CHARACTERIZATION OF DENDRIMER-HBSAG CONJUGATE

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KHOSRAVY MOHAMMAD SADEQ; SHAFIEE ARDESTANI MEHDI; AHANGARI COHAN REZA; DOROUD DELARAM; AMINI SAFIEH; MOMEN SEYED BAHMAN; ATYABI SEYED MOHAMMAD; HEYDARI HOSSIEN; VAHABPOUR ROHOLLAH

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Journal: VACCINE RESEARCH Year:2014 | Volume:1 | Issue:2 Page(s): 24-28

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Title

DESIGN, SYNTHESIS, PHYSICOCHEMICAL AND IMMUNOLOGICAL CHARACTERIZATION OF DENDRIMER-HBSAG CONJUGATE

Author(s)

Keywords

HBSAG

DENDRIMERS

VACCINE

CONJUGATE

Abstract

Introduction: Manufacturing new Hepatitis B virus VACCINEs, specifically by the use of nanoparticles, is of high global interest. In this paper, a new structure of nano-sized hepatitis B virus’ surface antigen (HBSAG) was generated by conjugation with DENDRIMERS. Methods: The physicochemical properties of the CONJUGATE were characterized by zeta potential and size distribution analyses and FT-IR spectrometry. Results: The results confirmed the conjugation between HBSAG and the DENDRIMERS. Immunological assays indicated that the immunogenicity of the CONJUGATEd HBSAG is more than HBSAG alone.Conclusion: In the current study, a cost-effective, biodegradable and biocompatible polymer was used to enhance the immunogenicity of HBSAG. Also, further investigations are required to explore the mechanisms of action of this nanocomplex VACCINE candidate.

Cites

G2 Dendrimer as a Carrier Can Enhance Immune Responses Against HCV-NS3 Protein in BALB/c Mice

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APA: Copy

KHOSRAVY, MOHAMMAD SADEQ, SHAFIEE ARDESTANI, MEHDI, AHANGARI COHAN, REZA, DOROUD, DELARAM, AMINI, SAFIEH, MOMEN, SEYED BAHMAN, ATYABI, SEYED MOHAMMAD, HEYDARI, HOSSIEN, & VAHABPOUR, ROHOLLAH. (2014). DESIGN, SYNTHESIS, PHYSICOCHEMICAL AND IMMUNOLOGICAL CHARACTERIZATION OF DENDRIMER-HBSAG CONJUGATE. VACCINE RESEARCH, 1(2), 24-28. SID. https://sid.ir/paper/344372/en

Vancouver: Copy

KHOSRAVY MOHAMMAD SADEQ, SHAFIEE ARDESTANI MEHDI, AHANGARI COHAN REZA, DOROUD DELARAM, AMINI SAFIEH, MOMEN SEYED BAHMAN, ATYABI SEYED MOHAMMAD, HEYDARI HOSSIEN, VAHABPOUR ROHOLLAH. DESIGN, SYNTHESIS, PHYSICOCHEMICAL AND IMMUNOLOGICAL CHARACTERIZATION OF DENDRIMER-HBSAG CONJUGATE. VACCINE RESEARCH[Internet]. 2014;1(2):24-28. Available from: https://sid.ir/paper/344372/en

IEEE: Copy

MOHAMMAD SADEQ KHOSRAVY, MEHDI SHAFIEE ARDESTANI, REZA AHANGARI COHAN, DELARAM DOROUD, SAFIEH AMINI, SEYED BAHMAN MOMEN, SEYED MOHAMMAD ATYABI, HOSSIEN HEYDARI, and ROHOLLAH VAHABPOUR, “DESIGN, SYNTHESIS, PHYSICOCHEMICAL AND IMMUNOLOGICAL CHARACTERIZATION OF DENDRIMER-HBSAG CONJUGATE,” VACCINE RESEARCH, vol. 1, no. 2, pp. 24–28, 2014, [Online]. Available: https://sid.ir/paper/344372/en

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