Could Trivalent LAIV Protect Against Both Genetic Lineages of Influenza B Virus?

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Irina Kiseleva; Ekaterina Stepanova; Krutikova Elena; Svetlana Donina; Andrey Rekstin; Ekaterina Bazhenova; Pisareva Maria; Anastasia Katelnikova; Kirill Kryshen; Muzhikyan Arman; Grigorieva Elena; Larisa Rudenko

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Journal: VACCINE RESEARCH Year:2019 | Volume:6 | Issue:1 Page(s): 13-24

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Title

Could Trivalent LAIV Protect Against Both Genetic Lineages of Influenza B Virus?

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Keywords

influenza

influenza B virus

live attenuated influenza vaccine

cross-protective activity

Abstract

Introduction: The global co-circulation of two influenza B virus genetic lineages known as B/Yamagata and B/Victoria may lead to a mismatch between the circulating virus and the strain recommended for use in influenza vaccines. Little is known about the protective efficacy of unmatched influenza B strains, especially when it comes to live attenuated influenza vaccine. The main purpose of this study was to demonstrate the viability of using live attenuated influenza vaccine developed on B/USSR/60/69 backbone to protect against heterologous influenza B challenge infection. Methods: To estimate the potential crossprotective activity of mono-and trivalent live attenuated vaccines based on B/Victoria or B/Yamagata genetic lineage virus against a heterological challenge, ferrets were given one dose of vaccine and then were challenged with influenza B virus. The ferrets were then monitored for clinical signs associated with influenza infection. Samples of the ferrets’ airways were tested for the presence of the challenge virus. Results: Mono-and trivalent live attenuated influenza vaccines were shown to be safe and cross-protective against genetically different influenza B viruses based on virological and histological data and clinical signs. A lower titer of heterologous challenge virus in the airways of the vaccinated ferrets compared to mock-vaccinated animals inoculated with the challenge virus was detected. Interestingly, B/Victoria-based vaccines were more cross-protective compared with B/Yamagata-based vaccines. Conclusion: In the case of mismatches of B component of the trivalent live attenuated influenza vaccine and lineage of the circulating influenza B viruses, one of the options could be using trivalent preparation containing a B/Victoria lineage component.

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APA: Copy

Irina, Kiseleva, Ekaterina, Stepanova, Krutikova, Elena, Svetlana, Donina, Andrey, Rekstin, Ekaterina, Bazhenova, Pisareva, Maria, Anastasia, Katelnikova, Kirill, Kryshen, Muzhikyan, Arman, Grigorieva, Elena, & Larisa, Rudenko. (2019). Could Trivalent LAIV Protect Against Both Genetic Lineages of Influenza B Virus?. VACCINE RESEARCH, 6(1), 13-24. SID. https://sid.ir/paper/344433/en

Vancouver: Copy

Irina Kiseleva, Ekaterina Stepanova, Krutikova Elena, Svetlana Donina, Andrey Rekstin, Ekaterina Bazhenova, Pisareva Maria, Anastasia Katelnikova, Kirill Kryshen, Muzhikyan Arman, Grigorieva Elena, Larisa Rudenko. Could Trivalent LAIV Protect Against Both Genetic Lineages of Influenza B Virus?. VACCINE RESEARCH[Internet]. 2019;6(1):13-24. Available from: https://sid.ir/paper/344433/en

IEEE: Copy

Kiseleva Irina, Stepanova Ekaterina, Elena Krutikova, Donina Svetlana, Rekstin Andrey, Bazhenova Ekaterina, Maria Pisareva, Katelnikova Anastasia, Kryshen Kirill, Arman Muzhikyan, Elena Grigorieva, and Rudenko Larisa, “Could Trivalent LAIV Protect Against Both Genetic Lineages of Influenza B Virus?,” VACCINE RESEARCH, vol. 6, no. 1, pp. 13–24, 2019, [Online]. Available: https://sid.ir/paper/344433/en

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