A Comparative Evaluation of Salivary Changes and Oral Indices in Pediatric Patients Having Chronic Kidney Disease and Juvenile Diabetes with Healthy Controls

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Shweta Chaudhary; Manasi Shimpi; Rajendra Shimpi; Laxmi Lakade; Shweta Jajoo; Sneha Desai

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Journal Paper

Paper Information

Journal: JOURNAL OF PEDIATRIC NEPHROLOGY Year:2019 | Volume:7 | Issue:2 Page(s): 0-0

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Title

A Comparative Evaluation of Salivary Changes and Oral Indices in Pediatric Patients Having Chronic Kidney Disease and Juvenile Diabetes with Healthy Controls

Author(s)

Keywords

Chronic Kidney Disease

Renal Dysfunction

Saliva

Cystatin-C

Diagnosis

Abstract

Background and Aim: Chronic Kidney Disease is a common condition seen in Juvenile diabetes with 90% of renal impairment patients displaying a wide spectrum of oral manifestations in the hard and soft tissues including changes of the Salivary composition and flow rate. There is an increase in the serum Cystatin-C, urea and creatinine levels in these patients, which is reflected in the Saliva. This study was conducted to assess the changes in Salivary levels of Cystatin-C, urea, and creatinine as well as oral – Decayed, Missing and Filled Teeth Index (DMFT) and gingival indices in pediatric patients suffering from chronic renal disease and juvenile diabetes and compare them with healthy individuals. Methods: Fifteen patients with juvenile diabetes suffering from chronic renal disease and 15 healthy controls aged 2-18 years were included in the study. Their Saliva was analyzed for creatinine, Cystatin-C and urea levels using an auto-analyzer and correlated with their existing serum levels. DMFT, gingival index, gingival bleeding and gingival enlargement indices were also assessed. Results: Increased levels of Salivary cystatin C, urea (p value <0. 001) and creatinine (p value =0. 001) were seen in the cases. The deft value was significantly lower (p value <0. 001) while the gingival index, gingival bleeding index, and gingival enlargement index were significantly higher in the subjects with renal impairment. Conclusion: Chronic Kidney Disease results in many metabolic changes in the body, necessitating frequent biochemical blood analysis. Saliva, being a non-invasive, simple and rapid adjunctive tool, can be used for diagnosing and staging the disease and to check the progression of the condition.

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References

Cystatin C estimated glomerular filtration rate to assess renal function in early stages of autosomal dominant polycystic kidney disease

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APA: Copy

Shweta, Chaudhary, Manasi, Shimpi, Rajendra, Shimpi, Laxmi, Lakade, Shweta, Jajoo, & Sneha, Desai. (2019). A Comparative Evaluation of Salivary Changes and Oral Indices in Pediatric Patients Having Chronic Kidney Disease and Juvenile Diabetes with Healthy Controls. JOURNAL OF PEDIATRIC NEPHROLOGY, 7(2), 0-0. SID. https://sid.ir/paper/344460/en

Vancouver: Copy

Shweta Chaudhary, Manasi Shimpi, Rajendra Shimpi, Laxmi Lakade, Shweta Jajoo, Sneha Desai. A Comparative Evaluation of Salivary Changes and Oral Indices in Pediatric Patients Having Chronic Kidney Disease and Juvenile Diabetes with Healthy Controls. JOURNAL OF PEDIATRIC NEPHROLOGY[Internet]. 2019;7(2):0-0. Available from: https://sid.ir/paper/344460/en

IEEE: Copy

Chaudhary Shweta, Shimpi Manasi, Shimpi Rajendra, Lakade Laxmi, Jajoo Shweta, and Desai Sneha, “A Comparative Evaluation of Salivary Changes and Oral Indices in Pediatric Patients Having Chronic Kidney Disease and Juvenile Diabetes with Healthy Controls,” JOURNAL OF PEDIATRIC NEPHROLOGY, vol. 7, no. 2, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/344460/en

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