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Title

Clinicopathological Spectrum and Treatment Outcome of Clinically Suspected Rapidly Progressive Glomerulonephritis: An Analysis of 35 Cases in a Tertiary Care Center, Bangladesh

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Abstract

 Background and Aim: Rapidly progressive glomeruloNephritis (RPGN) is characterized by a rapid decline in the renal function and urinary abnormalities. There is limited information on epidemiological factors and clinical and histopathological patterns of RPGN from developing countries. Therefore, the objective of this study was to identify the etiology, clinical features, histopathological patterns, and treatment outcomes of patients with clinically suspected RPGN. Methods: This retrospective study was conducted in the Pediatric Nephrology Department of Bangabandhu Sheikh Mujib Medical University from January 2014 to January 2019. Patients with clinically suspected RPGN that underwent renal biopsy were enrolled in this study. Results: Thirty-five patients were recruited in this study. Macroscopic hematuria, edema, hypertension, uremia, and oliguria were common clinical presentations. Diffuse proliferative GN (28. 5%) and crescentic GN (22. 8%) were the most common histological diagnoses in this study. Immune mediated GN (62%) followed by idiopathic GN (25%) were found to be the most frequent cause of crescentic GN. Renal replacement therapy was required in 45% of the cases and 11. 4% of the patients developed end-stage renal disease. Conclusion: Renal histology is an integral part of the investigation of patients with suspected RPGN for both diagnostic and prognostic purposes. Diffuse proliferative GN was the most common histopathological diagnosis in patients with clinical RPGN in our population. Preservation of renal function depends on early intervention and detection of RPGN in pediatric patients.

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    APA: Copy

    Roy, Ranjit Ranjan, Arju, Jahanara, Sultana, Jakia, Rahman, Farhana, Hasan, Mohammad Imrul, Mamun, Abdullah Al, Jesmin, Tahmina, Begum, Afroza, Haque, Sayed Saimul, Muin Uddin, Golam, & Rahman, Md. Habibur. (2019). Clinicopathological Spectrum and Treatment Outcome of Clinically Suspected Rapidly Progressive Glomerulonephritis: An Analysis of 35 Cases in a Tertiary Care Center, Bangladesh. JOURNAL OF PEDIATRIC NEPHROLOGY, 7(3), 0-0. SID. https://sid.ir/paper/344470/en

    Vancouver: Copy

    Roy Ranjit Ranjan, Arju Jahanara, Sultana Jakia, Rahman Farhana, Hasan Mohammad Imrul, Mamun Abdullah Al, Jesmin Tahmina, Begum Afroza, Haque Sayed Saimul, Muin Uddin Golam, Rahman Md. Habibur. Clinicopathological Spectrum and Treatment Outcome of Clinically Suspected Rapidly Progressive Glomerulonephritis: An Analysis of 35 Cases in a Tertiary Care Center, Bangladesh. JOURNAL OF PEDIATRIC NEPHROLOGY[Internet]. 2019;7(3):0-0. Available from: https://sid.ir/paper/344470/en

    IEEE: Copy

    Ranjit Ranjan Roy, Jahanara Arju, Jakia Sultana, Farhana Rahman, Mohammad Imrul Hasan, Abdullah Al Mamun, Tahmina Jesmin, Afroza Begum, Sayed Saimul Haque, Golam Muin Uddin, and Md. Habibur Rahman, “Clinicopathological Spectrum and Treatment Outcome of Clinically Suspected Rapidly Progressive Glomerulonephritis: An Analysis of 35 Cases in a Tertiary Care Center, Bangladesh,” JOURNAL OF PEDIATRIC NEPHROLOGY, vol. 7, no. 3, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/344470/en

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