THE SERUM AMYLOID β LEVEL IN MULTIPLE SCLEROSIS: A CASE- CONTROL STUDY

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ETEMADIFAR MASOUD; GHADIMI MOZHGAN; GHADIMI KEYVAN; ALSAHEBFOSOUL FERESHTEH

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Journal Paper

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Journal: Caspian Journal of Neurological Sciences Year:2017 | Volume:3 | Issue:11 Page(s): 214-221

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Title

THE SERUM AMYLOID β LEVEL IN MULTIPLE SCLEROSIS: A CASE- CONTROL STUDY

Author(s)

ETEMADIFAR MASOUD | GHADIMI MOZHGAN | GHADIMI KEYVAN | ALSAHEBFOSOUL FERESHTEH | Issue Writer Certificate

Keywords

MULTIPLE SCLEROSIS

AMYLOID

ENZYME-LINKED IMMUNOSORBENT ASSAY

Abstract

Background: MULTIPLE SCLEROSIS (MS) is one of the most common autoimmune diseases in adults that cause disability in patients. Different studies were conducted on more rapid diagnosis of the disease such as measuring serum or cerebrospinal fluid (CSF) contents.Objectives: The current study aimed at measuring AMYLOID b (Ab) serum levels in patients with relapsing-remitting MS.Materials and Methods: In the current case-control study, the serum levels of A were measured in 48 patients with RRMS and 33 healthy controls using the ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA) technique in Isfahan, Iran, from 2014 to 2016. Data analysis was conducted with SPSS.Results: The mean serum level of Ab in the case (patients with RRMS) and control groups were 192.75±125.65 and 128.11±85.20 pg/mL, respectively; so serum Ab levels in the RRMS group was significantly higher than healthy controls (p=0.02). Also, there was a positive significant correlation between the serum Ab levels and the expanded disability status scale (EDSS) (r=+0.85, p<0.0001).Conclusions: Owing to the increase of serum Ab level in patients with RRMS and its significant increase in severe MS cases (higher EDSS scores), so serum Ablevel can be considered as a marker for MS and its progression.

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APA: Copy

ETEMADIFAR, MASOUD, GHADIMI, MOZHGAN, GHADIMI, KEYVAN, & ALSAHEBFOSOUL, FERESHTEH. (2017). THE SERUM AMYLOID β LEVEL IN MULTIPLE SCLEROSIS: A CASE- CONTROL STUDY. CASPIAN JOURNAL OF NEUROLOGICAL SCIENCES, 3(11), 214-221. SID. https://sid.ir/paper/344661/en

Vancouver: Copy

ETEMADIFAR MASOUD, GHADIMI MOZHGAN, GHADIMI KEYVAN, ALSAHEBFOSOUL FERESHTEH. THE SERUM AMYLOID β LEVEL IN MULTIPLE SCLEROSIS: A CASE- CONTROL STUDY. CASPIAN JOURNAL OF NEUROLOGICAL SCIENCES[Internet]. 2017;3(11):214-221. Available from: https://sid.ir/paper/344661/en

IEEE: Copy

MASOUD ETEMADIFAR, MOZHGAN GHADIMI, KEYVAN GHADIMI, and FERESHTEH ALSAHEBFOSOUL, “THE SERUM AMYLOID β LEVEL IN MULTIPLE SCLEROSIS: A CASE- CONTROL STUDY,” CASPIAN JOURNAL OF NEUROLOGICAL SCIENCES, vol. 3, no. 11, pp. 214–221, 2017, [Online]. Available: https://sid.ir/paper/344661/en

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