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Information Journal Paper

Title

Evaluation of Diagnostic Threshold of Amylase and Lipase Enzymes in Diagnosis of Acute Pancreatitis and Their Sensitivity and Specificity

Pages

  128-132

Abstract

 Objectives: Every sudden and non-traumatic disorder with a major clinical manifestation in the abdomen is considered as an acute abdomen and requires urgent surgery, considering the fact that it is a cause of acute Pancreatitis, which is usually associated with increased blood Amylase and Lipase levels. Therefore, the diagnostic value of Amylase, Lipase enzymes, their Sensitivity, and Specificity along with their positive and negative predictive value in the diagnosis of acute Pancreatitis were evaluated. Materials and Methods: This descriptive-analytical study examined 244 patients who referred to Imam Reza and Sina Hospitals of Tabriz. The diagnostic values of two thresholds of 110 and 550 IU/L for Amylase, and 80 and 400 IU/L for Lipase were studied. Results: The results showed that 142 (58. 2%) of the patients were female. The mean age was 57. 97 ± 21. 22 years old. Eighty-one patients (33. 2%) had acute Pancreatitis. At a cut-off of 110 IU/L, the Sensitivity, Specificity, positive predictive value, and negative predictive value of Amylase enzyme were 0. 762, 0. 407, 0. 736 and 0. 988 and at a cut-off of 550 IU/L, they were 0. 598, 0. 943, 0. 876 and 0. 77, respectively. In the case of Lipase, at cut-offs of 80 and 400 IU/L, the Sensitivity of 0. 84 and 0. 519, the Specificity of 0. 552 and 0. 847, positive predictive value of 0. 482 and 0. 627, negative predictive value of 0. 874 and 0. 87. Conclusions: The results showed that as the detection threshold increased, the Specificity of tests increased, but the Sensitivity decreased. In addition, studying the level of Lipase and Amylase enzymes can help in the diagnosis of acute Pancreatitis.

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    APA: Copy

    Azari Amghani, Younes, & ABRI AGHDAM, BABAK. (2018). Evaluation of Diagnostic Threshold of Amylase and Lipase Enzymes in Diagnosis of Acute Pancreatitis and Their Sensitivity and Specificity. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, 5(2), 128-132. SID. https://sid.ir/paper/344986/en

    Vancouver: Copy

    Azari Amghani Younes, ABRI AGHDAM BABAK. Evaluation of Diagnostic Threshold of Amylase and Lipase Enzymes in Diagnosis of Acute Pancreatitis and Their Sensitivity and Specificity. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES[Internet]. 2018;5(2):128-132. Available from: https://sid.ir/paper/344986/en

    IEEE: Copy

    Younes Azari Amghani, and BABAK ABRI AGHDAM, “Evaluation of Diagnostic Threshold of Amylase and Lipase Enzymes in Diagnosis of Acute Pancreatitis and Their Sensitivity and Specificity,” CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, vol. 5, no. 2, pp. 128–132, 2018, [Online]. Available: https://sid.ir/paper/344986/en

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