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Information Journal Paper

Title

The Association of C381T Polymorphism in Notch3 Gene With Cerebral Stroke

Pages

  253-257

Abstract

 Objectives: Cerebral stroke is a common multifactorial trait that does not follow Mendelian pattern of inheritance. The phenomena of gene-gene or gene-environment interactions may be responsible for the multifactorial traits. Any mutation may be associated with silencing implicated in other disorders. This case-control study explored the association between Notch3 polymorphism and stroke in Iranian-Azeri population. Materials and Methods: In this case-control study, C381T polymorphism in Notch3 gene was evaluated among 65 patients with ischemic stroke and 65 individuals without any stroke as control group. The samples were recruited from 5 clinical centers during 2014-2015. PCR-SSCP and sequencing methods were used to obtain the data. Results: In this study, the frequencies of C and T alleles in the patient group were 85% and 15%, and in the control group were 94% and 6%, respectively. The frequencies of CC, CT and TT genotypes were 72%, 26% and 2% in the patient group, and 88%, 12% and 0% in the control group, respectively. Both control and patient groups had significant difference considering their both allele and genotype frequencies. The individuals with C381T polymorphism in Notch3 gene were in a significantly higher risk of thrombotic stroke (P = 0. 02, CI: 0. 128-0. 256: 95%, odds ratio [OR]: 2. 72). Conclusions: Our results showed that combination of T allele of this gene conferred higher risk for Cerebral stroke. The interaction of gene mutation with post-translation modification may serve as a novel field for stroke research.

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    APA: Copy

    Ghoreishizadeh, Afsoon, TABATABAEI, SEYED MAHMOUD, Adibi, Ashkan, & Dastar, saba. (2018). The Association of C381T Polymorphism in Notch3 Gene With Cerebral Stroke. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, 5(3), 253-257. SID. https://sid.ir/paper/345022/en

    Vancouver: Copy

    Ghoreishizadeh Afsoon, TABATABAEI SEYED MAHMOUD, Adibi Ashkan, Dastar saba. The Association of C381T Polymorphism in Notch3 Gene With Cerebral Stroke. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES[Internet]. 2018;5(3):253-257. Available from: https://sid.ir/paper/345022/en

    IEEE: Copy

    Afsoon Ghoreishizadeh, SEYED MAHMOUD TABATABAEI, Ashkan Adibi, and saba Dastar, “The Association of C381T Polymorphism in Notch3 Gene With Cerebral Stroke,” CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, vol. 5, no. 3, pp. 253–257, 2018, [Online]. Available: https://sid.ir/paper/345022/en

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