APOE AND CPT1-A PROMOTER METHYLATION AND EXPRESSION PROFILES IN PATIENTS WITH SCHIZOPHRENIA

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KORDI TAMANDANI DOR MOHAMMAD; NAJAFI MARYAM; MOJAHAD AZIZALL

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Journal: Gene, Cell and Tissue Year:2014 | Volume:1 | Issue:1 Page(s): 0-0

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Title

APOE AND CPT1-A PROMOTER METHYLATION AND EXPRESSION PROFILES IN PATIENTS WITH SCHIZOPHRENIA

Author(s)

KORDI TAMANDANI DOR MOHAMMAD | NAJAFI MARYAM | MOJAHAD AZIZALL | Issue Writer Certificate

Keywords

APOLIPOPROTEINS E

CARNITINE PALMITOYLTRANSFERASE 1A

HUMAN

SCHIZOPHRENIA

Abstract

Background: Apo-lipoprotein E (APOE) and Carnitine palmitoyltransferase1-A (CPT1-A) genes are well known to be involved in the pathophysiology of psychiatric disorders such as SCHIZOPHRENIA but regarding their CPG island methylation status data is sparse.Objectives: The aims of the current study were to highlight the effect of the promoter “hypermethylation” in the development of SCZ.Patients and Methods: Genomic DNA was extracted from peripheral blood of 80 patients with SCHIZOPHRENIA and 71 healthy controls. The Methylation pattern was studied using Methylation-Specific PCR. RNA expression analysis was performed on extracted RNA from blood samples of patients suffering from SCHIZOPHRENIA (n = 17) and healthy controls (n = 17).Results: Frequency of the APOE and CPT1-A methylation show insignificant relationship between cases and controls. Estimates of relative gene expression revealed no significant statistical association of the APOE and CPT1-A genes between schizophrenic patients and healthy controls.Conclusions: This is the first evidence regarding APOE and CPT1-A gene methylation and their expression profile related to risk of SCHIZOPHRENIA which indicate no significant association between the APOE and CPT1-A gene methylation and development of SCHIZOPHRENIA.

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APA: Copy

KORDI TAMANDANI, DOR MOHAMMAD, NAJAFI, MARYAM, & MOJAHAD, AZIZALL. (2014). APOE AND CPT1-A PROMOTER METHYLATION AND EXPRESSION PROFILES IN PATIENTS WITH SCHIZOPHRENIA. GENE, CELL AND TISSUE, 1(1), 0-0. SID. https://sid.ir/paper/345074/en

Vancouver: Copy

KORDI TAMANDANI DOR MOHAMMAD, NAJAFI MARYAM, MOJAHAD AZIZALL. APOE AND CPT1-A PROMOTER METHYLATION AND EXPRESSION PROFILES IN PATIENTS WITH SCHIZOPHRENIA. GENE, CELL AND TISSUE[Internet]. 2014;1(1):0-0. Available from: https://sid.ir/paper/345074/en

IEEE: Copy

DOR MOHAMMAD KORDI TAMANDANI, MARYAM NAJAFI, and AZIZALL MOJAHAD, “APOE AND CPT1-A PROMOTER METHYLATION AND EXPRESSION PROFILES IN PATIENTS WITH SCHIZOPHRENIA,” GENE, CELL AND TISSUE, vol. 1, no. 1, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/345074/en

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