THE EFFECTS OF SEROTONIN RECEPTOR ANTAGONISTS ON CONTRACTION AND RELAXATION RESPONSES INDUCED BY ELECTRICAL STIMULATION IN THE RAT SMALL INTESTINE

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FARAJIAN MASHHADI FARZANEH; NAYLOR ROBERT J.; JAVID FARIDEH A.

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Journal: Gene, Cell and Tissue Year:2014 | Volume:1 | Issue:1 Page(s): 0-0

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Title

THE EFFECTS OF SEROTONIN RECEPTOR ANTAGONISTS ON CONTRACTION AND RELAXATION RESPONSES INDUCED BY ELECTRICAL STIMULATION IN THE RAT SMALL INTESTINE

Author(s)

FARAJIAN MASHHADI FARZANEH | NAYLOR ROBERT J. | JAVID FARIDEH A. | Issue Writer Certificate

Keywords

ELECTRIC STIMULATION THERAPY

SEROTONIN 5-HT1 RECEPTOR ANTAGONISTS

INTESTINE

SMALL

Abstract

Background: The main source of 5-HT in body is in enterchromafin cells of INTESTINE, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT.Objectives: To study the role of endogenous 5-HT on modulation of contraction and relaxation responses induced by electrical field stimulation (EFS) in different regions of the rat INTESTINE. Materials and Methods: Segments taken from the rat duodenum, jejunum, mid and terminal ileum were vertically mounted, connected to a transducer and exposed to EFS with different frequencies in the absence and presence of various inhibitors of enteric mediators i. e. specific 5-HT receptor antagonists.Results: EFS-induced responses were sensitive to TTX and partly to atropine, indicating a major neuronal involvement and a cholinergic system. Pre-treatment with WAY100635 (a 5-HT1A receptor antagonist) and granisetron up to 10.0 mM, GR113808 (a 5-HT4 receptor antagonist), methysergide and ritanserin up to 1.0 mM, failed to modify responses to EFS inall examined tissues. In the presence of SB258585 1.0 mM (a 5-HT6 receptor antagonist) there was a trend to enhance contraction in the proximal part of the INTESTINE and reduce contraction in the distal part. Pre-treatment with SB269970A 1.0 mM (5-HT7 receptor antagonist) induced a greater contractile response to EFS at 0.4 Hz only in the duodenum.Conclusions: The application of 5-HT1A, 5-HT2, 5-HT3, 5-HT4, 5-HT6 and 5-HT7 receptor antagonists, applied at concentrations lower than 1.0 mM did not modify the EFS-induced contraction and relaxation responses, whichsuggests the unlikely involvement of endogenous 5-HT in mediating responses to EFS in the described test conditions.

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APA: Copy

FARAJIAN MASHHADI, FARZANEH, NAYLOR, ROBERT J., & JAVID, FARIDEH A.. (2014). THE EFFECTS OF SEROTONIN RECEPTOR ANTAGONISTS ON CONTRACTION AND RELAXATION RESPONSES INDUCED BY ELECTRICAL STIMULATION IN THE RAT SMALL INTESTINE. GENE, CELL AND TISSUE, 1(1), 0-0. SID. https://sid.ir/paper/345079/en

Vancouver: Copy

FARAJIAN MASHHADI FARZANEH, NAYLOR ROBERT J., JAVID FARIDEH A.. THE EFFECTS OF SEROTONIN RECEPTOR ANTAGONISTS ON CONTRACTION AND RELAXATION RESPONSES INDUCED BY ELECTRICAL STIMULATION IN THE RAT SMALL INTESTINE. GENE, CELL AND TISSUE[Internet]. 2014;1(1):0-0. Available from: https://sid.ir/paper/345079/en

IEEE: Copy

FARZANEH FARAJIAN MASHHADI, ROBERT J. NAYLOR, and FARIDEH A. JAVID, “THE EFFECTS OF SEROTONIN RECEPTOR ANTAGONISTS ON CONTRACTION AND RELAXATION RESPONSES INDUCED BY ELECTRICAL STIMULATION IN THE RAT SMALL INTESTINE,” GENE, CELL AND TISSUE, vol. 1, no. 1, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/345079/en

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