ASSOCIATION STUDY OF THE PTPN22 GENE POLYMORPHISMS WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN LORESTAN PROVINCE OF IRAN

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Shahrokhi Seyedeh Zahra; KAZEMI NEZHAD SEYED REZA; BAHARVAND AHMADI SHARAM; AKHOOND MOHAMMAD REZA

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Journal: Gene, Cell and Tissue Year:2017 | Volume:4 | Issue:3 Page(s): 0-0

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Title

ASSOCIATION STUDY OF THE PTPN22 GENE POLYMORPHISMS WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN LORESTAN PROVINCE OF IRAN

Author(s)

Shahrokhi Seyedeh Zahra | KAZEMI NEZHAD SEYED REZA | BAHARVAND AHMADI SHARAM | AKHOOND MOHAMMAD REZA | Issue Writer Certificate

Keywords

POLYMORPHISM

SYSTEMIC LUPUS ERYTHEMATOSUS

PTPN22 GENE

Abstract

Background: The protein tyrosine phosphatase non-receptor 22 (PTPN22) gene encodes the lymphoid protein tyrosinephosphatase.Recent studies demonstrated the association between the+1858C>T, -1123G>C variants ofPTPN22 gene, and different autoimmune diseases. The current study aimed at examining the association between the POLYMORPHISM of PTPN22 GENE and SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) in the Southwest of Iran.Methods: The current study included 120 patients with SLE and 120 healthy volunteers as a control group. Genomic DNA was extracted and the genotyping was performed based on the PCR-restriction fragment length POLYMORPHISM (PCR-RFLP) method.Results: Frequency of 1858T allele (P<0.001, OR=0.44, 95% CI=0.291 to 0.663) showed association and frequency of 1123C allele (P= 0.307, OR=0.811, 95% CI=0.543 to 1.212) showed no association with SLE in patients compared with the control group in the studied population.Conclusions: Statistical analysis showed no relationship among gender, genotype, and SLE risk. However, there was a significant relationship between age and the SLE risk (P=0.006).

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APA: Copy

Shahrokhi, Seyedeh Zahra, KAZEMI NEZHAD, SEYED REZA, BAHARVAND AHMADI, SHARAM, & AKHOOND, MOHAMMAD REZA. (2017). ASSOCIATION STUDY OF THE PTPN22 GENE POLYMORPHISMS WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN LORESTAN PROVINCE OF IRAN. GENE, CELL AND TISSUE, 4(3), 0-0. SID. https://sid.ir/paper/345129/en

Vancouver: Copy

Shahrokhi Seyedeh Zahra, KAZEMI NEZHAD SEYED REZA, BAHARVAND AHMADI SHARAM, AKHOOND MOHAMMAD REZA. ASSOCIATION STUDY OF THE PTPN22 GENE POLYMORPHISMS WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN LORESTAN PROVINCE OF IRAN. GENE, CELL AND TISSUE[Internet]. 2017;4(3):0-0. Available from: https://sid.ir/paper/345129/en

IEEE: Copy

Seyedeh Zahra Shahrokhi, SEYED REZA KAZEMI NEZHAD, SHARAM BAHARVAND AHMADI, and MOHAMMAD REZA AKHOOND, “ASSOCIATION STUDY OF THE PTPN22 GENE POLYMORPHISMS WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN LORESTAN PROVINCE OF IRAN,” GENE, CELL AND TISSUE, vol. 4, no. 3, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/345129/en

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