SPINAL CORD INJURY REPAIR BY INTRATHECAL INFUSION OF STROMAL CELL-DERIVED FACTOR-1/CXC CHEMOKINE RECEPTOR 4 IN A RAT MODEL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GOLIPOOR ZOLEIKHA; SOLEIMANI ASL SARA; MEHRAEIN FERESHTEH; ALIZADEH AKRAM; ASADI EBRAHIM; SARBISHEGI MARYAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Gene, Cell and Tissue Year:2016 | Volume:3 | Issue:2 Page(s): 1-6

Download Full-Text

View:

204

Download:

143

Cites:

Information Journal Paper

Title

SPINAL CORD INJURY REPAIR BY INTRATHECAL INFUSION OF STROMAL CELL-DERIVED FACTOR-1/CXC CHEMOKINE RECEPTOR 4 IN A RAT MODEL

Author(s)

Keywords

SDF-1

CXCR4

SPINAL CORD INJURY

RAT

Abstract

Background: Stromal cell-derived factor-1 (SDF-1)/CXC Chemokine receptor 4 (CXCR4) is an important cytokine, with multiple functions, which plays a crucial role in the recruitment of multiple stem cell types in the defect sites of central nervous system (CNS). Various strategies have been managed to improve functional recovery after SPINAL CORD INJURY (SCI). One of these strategies is the use of factors to limit damage and increase recovery.Objectives: In this study we investigated the effect of SDF-1 in SPINAL CORD INJURY repair in a RAT model. Materials and Methods: Adult male Wistar RATs were randomlydivided to four groups (n=5) as follows: Sham, SCI, SDF-1 and Vehicle. SPINAL CORD INJURY model was created by contusion of T8-T9 by clips and SDF-1 infusion pump implanted in the neck region. One week after injury, 5-Bromo-20-Deoxyuridine (BrdU) was injected to trace the proliferative cells. Basso-Beattie-Bresnahan (BBB) test was performed to evaluate locomotor activity following SCI. Immunohistochemistry test was performed to determine proliferating cells, and real time polymerase chain reaction (PCR) was performed to detect the CXCR4 cells in tissue.Results: Significant improvements in locomotor function were detected in the SDF-1 group compared with the SCI and vehicle groups (P < 0.05). The results showed that SDF-1 treatment increased proliferative cells at the SPINAL CORD INJURY site. Real time PCR revealed that these proliferative cells are CXCR4 positive that intake Bromodeoxyuridine (Brdu).Conclusions: These results showed that the administration of SDF-1a increases the number of proliferating cells in the injured area in the spinal cord and improves functional recovery.

Cites

No record.

References

No record.

Cite

APA: Copy

GOLIPOOR, ZOLEIKHA, SOLEIMANI ASL, SARA, MEHRAEIN, FERESHTEH, ALIZADEH, AKRAM, ASADI, EBRAHIM, & SARBISHEGI, MARYAM. (2016). SPINAL CORD INJURY REPAIR BY INTRATHECAL INFUSION OF STROMAL CELL-DERIVED FACTOR-1/CXC CHEMOKINE RECEPTOR 4 IN A RAT MODEL. GENE, CELL AND TISSUE, 3(2), 1-6. SID. https://sid.ir/paper/345143/en

Vancouver: Copy

GOLIPOOR ZOLEIKHA, SOLEIMANI ASL SARA, MEHRAEIN FERESHTEH, ALIZADEH AKRAM, ASADI EBRAHIM, SARBISHEGI MARYAM. SPINAL CORD INJURY REPAIR BY INTRATHECAL INFUSION OF STROMAL CELL-DERIVED FACTOR-1/CXC CHEMOKINE RECEPTOR 4 IN A RAT MODEL. GENE, CELL AND TISSUE[Internet]. 2016;3(2):1-6. Available from: https://sid.ir/paper/345143/en

IEEE: Copy

ZOLEIKHA GOLIPOOR, SARA SOLEIMANI ASL, FERESHTEH MEHRAEIN, AKRAM ALIZADEH, EBRAHIM ASADI, and MARYAM SARBISHEGI, “SPINAL CORD INJURY REPAIR BY INTRATHECAL INFUSION OF STROMAL CELL-DERIVED FACTOR-1/CXC CHEMOKINE RECEPTOR 4 IN A RAT MODEL,” GENE, CELL AND TISSUE, vol. 3, no. 2, pp. 1–6, 2016, [Online]. Available: https://sid.ir/paper/345143/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops