SPECTROSCOPIC STUDIES ON THE INTERACTION OF ANTI CANCER ROSEMARY WITH CTDNA

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MOSTAFAVINIA SEYEDEH ELHAM; HOSHYAR REYHANE

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Gene, Cell and Tissue Year:2016 | Volume:3 | Issue:2 Page(s): 1-5

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Information Journal Paper

Title

SPECTROSCOPIC STUDIES ON THE INTERACTION OF ANTI CANCER ROSEMARY WITH CTDNA

Author(s)

MOSTAFAVINIA SEYEDEH ELHAM | HOSHYAR REYHANE | Issue Writer Certificate

Keywords

INTERACTION

DNA

ROSEMARY

SPECTROSCOPIC

Abstract

Background: Some herbal anticancer agents have direct INTERACTIONs with DNA.Objectives: The present study aimed to investigate the INTERACTION of ctDNA with ROSEMARY flowers.Materials and Methods: We used UV-Vis, fluorescence and circular dichroism (CD) SPECTROSCOPIC techniques.Results: The absorption of DNA at 260 nm increased on addition of ROSEMARY. Herb extract quench the fluorescence of EtBr bound to ctDNA. The Stern-Volmer constant (K) value for ROSEMARY extract is 0.39 (mg/mL)-1. Finally, the CD spectra indicate that ROSEMARY induces some conformational changes in ctDNA structure such as B to C-form transition.Conclusions: Our results illustrate that ROSEMARY extracts interact with ctDNA through minor groove binding. This is one of the molecular mechanisms underlying anticancer effects of ROSEMARY.

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APA: Copy

MOSTAFAVINIA, SEYEDEH ELHAM, & HOSHYAR, REYHANE. (2016). SPECTROSCOPIC STUDIES ON THE INTERACTION OF ANTI CANCER ROSEMARY WITH CTDNA. GENE, CELL AND TISSUE, 3(2), 1-5. SID. https://sid.ir/paper/345144/en

Vancouver: Copy

MOSTAFAVINIA SEYEDEH ELHAM, HOSHYAR REYHANE. SPECTROSCOPIC STUDIES ON THE INTERACTION OF ANTI CANCER ROSEMARY WITH CTDNA. GENE, CELL AND TISSUE[Internet]. 2016;3(2):1-5. Available from: https://sid.ir/paper/345144/en

IEEE: Copy

SEYEDEH ELHAM MOSTAFAVINIA, and REYHANE HOSHYAR, “SPECTROSCOPIC STUDIES ON THE INTERACTION OF ANTI CANCER ROSEMARY WITH CTDNA,” GENE, CELL AND TISSUE, vol. 3, no. 2, pp. 1–5, 2016, [Online]. Available: https://sid.ir/paper/345144/en

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