ALZHEIMER DISEASES (LETTER)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MADADI SOHEILA; MEHDIZADED MEHDI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Neuropsychophysiology Year:2014 | Volume:1 | Issue:2 Page(s): 0-0

Download Full-Text

View:

279

Download:

109

Cites:

Information Journal Paper

Title

ALZHEIMER DISEASES (LETTER)

Author(s)

MADADI SOHEILA | MEHDIZADED MEHDI | Issue Writer Certificate

Keywords

Not Registered.

Abstract

Alzheimer's disease (AD), the most common cause of dementia is accompanied by progressive memory loss and other cognitive functions. The conditionis estimated to affect approximately 36 million people, worldwide. AD is characterized by the presence of extracellular amyloid b (Ab) deposits, intracellular neurofibrillary tanglesand senile plaques in the cortex, hippocampus, basal forebrain and amygdale. Neurofibrillary tangles formation is the result of intracellular fibrillar aggregation of the microtubule-associated protein tau that is hyperphosphorylated and oxidized. Senile plaques consist of insoluble fibrillar Ab. It is established that Ab is formed after sequential cleavage of amyloid precursor protein and secreted to the extracellular space. It also inhibits hippocampal long-term potentiation and disrupts the synaptic plasticity. In addition, Ab accumulation induces an elevation in levels of reactive oxygen species (ROS) in neurons, leading to apoptotic neuronal death in rats and mice. Studies showed that the accumulation of Ab in brain plays an important role in the pathophysiology of AD and a close correlation exits between Ab procedure and the neurodegeneration process of AD. There exists evidence suggesting that memory impairment in AD begins with changes in hippocampal synaptic functions and then gradually progresses to neurodegeneration and neuronal loss in these patients.

Cites

No record.

References

No record.

Cite

APA: Copy

MADADI, SOHEILA, & MEHDIZADED, MEHDI. (2014). ALZHEIMER DISEASES (LETTER). AVICENNA JOURNAL OF NEURO PSYCHO PHYSIOLOGY, 1(2), 0-0. SID. https://sid.ir/paper/345216/en

Vancouver: Copy

MADADI SOHEILA, MEHDIZADED MEHDI. ALZHEIMER DISEASES (LETTER). AVICENNA JOURNAL OF NEURO PSYCHO PHYSIOLOGY[Internet]. 2014;1(2):0-0. Available from: https://sid.ir/paper/345216/en

IEEE: Copy

SOHEILA MADADI, and MEHDI MEHDIZADED, “ALZHEIMER DISEASES (LETTER),” AVICENNA JOURNAL OF NEURO PSYCHO PHYSIOLOGY, vol. 1, no. 2, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/345216/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops