Effect of Phenylhydrazine-Induced Hemolytic Anemia on Renal Cortex in Adult Mice: Protective Effect of Crocin

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ADIBMORADI M.; KALANTARI HESARI A.; SHAHROOZ R.; ASADI M.R.

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Journal: Journal of Veterinary Research Year:2018 | Volume:73 | Issue:1 Page(s): 63-70

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Title

Effect of Phenylhydrazine-Induced Hemolytic Anemia on Renal Cortex in Adult Mice: Protective Effect of Crocin

Author(s)

ADIBMORADI M. | KALANTARI HESARI A. | SHAHROOZ R. | ASADI M.R. | Issue Writer Certificate

Keywords

Hemolytic anemiaQ1

hypoxiaQ2

phenyl hydrazineQ1

crocinQ1

renal cortexQ2

Abstract

BACKGROUND: Hemolytic anemia and resultant hypoxia can cause a dysfunction in the body functions. Iron delivered from hemolysis of erythrocytes can also stimulate oxidative stress. OBJECTIVES: In this study, we aimed to investigate the protective effect of crocin on renal quality in animals that were exposed against Hemolytic anemia induced by phenilhydrazine. METHODS: Forty-nine adult male mice (20-25 g) were grouped within 7 groups. First group was control and treated with normal saline, and test groups were nominated as 2, 3, and 4 and were treated with phenyl hydrazine 2, 4, and 6 mg/100g/48 h (i. p. ). Animals in groups 5, 6, and 7 were treated with crocin (200 mg/k/day, i. p. ) in addition to 2, 4, and 6 mg/100g/48 h phenyl hydrazine. After 35 days, the blood samples were collected directly from the heart and after centrifugation (5 min and 3000 rpm), the serum samples were subjected to evaluate the Malondialehyde (MAD) level and total antioxidant capacity (TAC), and renal cortex was fixed in 10% formal saline for Paraffin sections after tissue processing sample staining with H&E method. RESULTS: This study showed that Hemolytic anemia affects proximal tubule of renal cortex, It was also shown that the phenylhydrazine administration resulted in a dose-dependent declining of TAC and the crocin administration was able to protect against TAC reduction. Moreover, PHN increased MDA level in serum in a dose-dependent manner. Co-administration of crocin with PHN significantly (p<0. 05) reduced the rate of lipid peroxidation, while those groups which were treated with crocin showed a remarkable improvement in testis parameters. CONCLUSIONS: These results indicate a protective effect of crocin against the anemiarelated hypoxia on renal parameters. The protective capacity of crocin might relate to its known antioxidant power.

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APA: Copy

ADIBMORADI, M., KALANTARI HESARI, A., SHAHROOZ, R., & ASADI, M.R.. (2018). Effect of Phenylhydrazine-Induced Hemolytic Anemia on Renal Cortex in Adult Mice: Protective Effect of Crocin. JOURNAL OF VETERINARY RESEARCH, 73(1 ), 63-70. SID. https://sid.ir/paper/34579/en

Vancouver: Copy

ADIBMORADI M., KALANTARI HESARI A., SHAHROOZ R., ASADI M.R.. Effect of Phenylhydrazine-Induced Hemolytic Anemia on Renal Cortex in Adult Mice: Protective Effect of Crocin. JOURNAL OF VETERINARY RESEARCH[Internet]. 2018;73(1 ):63-70. Available from: https://sid.ir/paper/34579/en

IEEE: Copy

M. ADIBMORADI, A. KALANTARI HESARI, R. SHAHROOZ, and M.R. ASADI, “Effect of Phenylhydrazine-Induced Hemolytic Anemia on Renal Cortex in Adult Mice: Protective Effect of Crocin,” JOURNAL OF VETERINARY RESEARCH, vol. 73, no. 1 , pp. 63–70, 2018, [Online]. Available: https://sid.ir/paper/34579/en

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