THE STUDY OF THE INHIBITION EFFECTS OF SATUREJA KHUZESTANIEA ESSENCE ON THE GENE EXPRESSION OF BLA-OXA-23 IN MULTIDRUG-RESISTANT STRAINS OF ACINETOBACTER BAUMANNII

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SAGHI HOSSEIN; AMIRI DASTJERDI FERDOES; ZAHEDI BAHADOR; Mohsen Pour Mohammad; KHORRAMI MAHMOUD; EFATI MAJID; ESMAEILI DAVOUD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Clinical Microbiology and Infection Year:2016 | Volume:3 | Issue:3 Page(s): 0-0

Download Full-Text

View:

311

Download:

237

Cites:

Information Journal Paper

Title

THE STUDY OF THE INHIBITION EFFECTS OF SATUREJA KHUZESTANIEA ESSENCE ON THE GENE EXPRESSION OF BLA-OXA-23 IN MULTIDRUG-RESISTANT STRAINS OF ACINETOBACTER BAUMANNII

Author(s)

Keywords

RT-PCR

BLA-OXA-23

SATUREJA KHUZESTANIEA

Abstract

Background: Acinetobacter baumannii is one of the Gram-negative bacteria in nosocomial infections that is resistant to treatment and control. The isolation of these bacteria is increasing significantly throughout the world. With increasing populations and a reduction in the use of synthetic drugs, many of these medicinal herbs are replacing other treatments.Objectives: The present study aims to investigate the inhibitory effects of SATUREJA KHUZESTANIEA essence on the expression of the antibiotic resistance genes bla-OXA-23 and Housekeeping DNA gyrase-A in multidrug-resistant strains of Acinetobacter baumannii, using the RT-PCR technique.Methods: SATUREJA KHUZESTANIEA essential oil was collected from the Barij essence research farm inMay2010. Five multidrug-resistant strains of Acinetobacter baumannii that contain the bla-OXA-23 and housekeeping DNA gyrase-A genes were selected. The disk diffusion method was used to evaluate the antimicrobial effect of essential oil, and major components were used. The minimum inhibitory concentration (MIC) values of theSatureja khuzestaniea essential oil were determined via a broth macro dilution assay, as recommended by the CLSI. Finally, an analysis of the bla-OXA-23 and Housekeeping DNA gyrase-A was performed using the RT-PCR technique.Results: The major components of SATUREJA KHUZESTANIEA essence are carvacrol (90.88%), r-cymene (3.11%), g terpinene (1.24%), and linalool (0.91%). The RT-PCR technique demonstrates thatSatureja khuzestaniea with an MIC of 0.2 mL/mL has the effect of reducing the expression of the antibiotic resistance gene bla-OXA-2. The essence has no inhibitory effect, however, on the Housekeeping DNA gyrase-A gene.Conclusions: This study indicates that SATUREJA KHUZESTANIEA essence has inhibitory effects on the gene expression of antibiotic resistance in bla-OXA-23 that has a high MIC. Given that this essence has a good inhibitory effect on gene expression in MDR Acinetobacter baumanniiand bla-OXA-23, the results indicate that it could be used as a natural way to prevent the growth of Acinetobacter baumannii.

Cites

IN-VITRO ANTIMICROBIAL ACTIVITY AND CHEMICAL COMPOSITION OF SATUREJA KHUZESTANICA JAMZAD ESSENTIAL OILS AGAINST MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII

References

No record.

Cite

APA: Copy

SAGHI, HOSSEIN, AMIRI DASTJERDI, FERDOES, ZAHEDI, BAHADOR, Mohsen Pour, Mohammad, KHORRAMI, MAHMOUD, EFATI, MAJID, & ESMAEILI, DAVOUD. (2016). THE STUDY OF THE INHIBITION EFFECTS OF SATUREJA KHUZESTANIEA ESSENCE ON THE GENE EXPRESSION OF BLA-^OXA-23 IN MULTIDRUG-RESISTANT STRAINS OF ACINETOBACTER BAUMANNII. AVICENNA JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTION, 3(3), 0-0. SID. https://sid.ir/paper/346828/en

Vancouver: Copy

SAGHI HOSSEIN, AMIRI DASTJERDI FERDOES, ZAHEDI BAHADOR, Mohsen Pour Mohammad, KHORRAMI MAHMOUD, EFATI MAJID, ESMAEILI DAVOUD. THE STUDY OF THE INHIBITION EFFECTS OF SATUREJA KHUZESTANIEA ESSENCE ON THE GENE EXPRESSION OF BLA-^OXA-23 IN MULTIDRUG-RESISTANT STRAINS OF ACINETOBACTER BAUMANNII. AVICENNA JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTION[Internet]. 2016;3(3):0-0. Available from: https://sid.ir/paper/346828/en

IEEE: Copy

HOSSEIN SAGHI, FERDOES AMIRI DASTJERDI, BAHADOR ZAHEDI, Mohammad Mohsen Pour, MAHMOUD KHORRAMI, MAJID EFATI, and DAVOUD ESMAEILI, “THE STUDY OF THE INHIBITION EFFECTS OF SATUREJA KHUZESTANIEA ESSENCE ON THE GENE EXPRESSION OF BLA-^OXA-23 IN MULTIDRUG-RESISTANT STRAINS OF ACINETOBACTER BAUMANNII,” AVICENNA JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTION, vol. 3, no. 3, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/346828/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops