TREATMENT OF HEPATITIS C VIRUS INFECTION IN THE HIV- INFECTED PATIENTS BY PEGYLATED INTERFERON AND RIBAVIRIN IN TEHRAN, IRAN

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PASHAEI ZANJANI ALI; ESMAEILPOUR NEGIN; RASOOLINEJAD MEHRNAZ; MORADNEJAD PARDIS; HEDAYAT YAGHOOBI MOJTABA

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Journal: Avicenna Journal of Clinical Microbiology and Infection Year:2017 | Volume:4 | Issue:3 Page(s): 0-0

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Title

TREATMENT OF HEPATITIS C VIRUS INFECTION IN THE HIV- INFECTED PATIENTS BY PEGYLATED INTERFERON AND RIBAVIRIN IN TEHRAN, IRAN

Author(s)

Keywords

HIV INFECTION

AIDS

HEPATITIS C

INTERFERON-ALFA

Abstract

Background and Objectives: Considering reductions in AIDS-related mortalities following effective anti-retroviral treatments in HIV/AIDS patients, HCV-associated liver diseases have turned into a major concern for HIV/HCV co-infected patients. The present study aims at determining SVR rates in HIV/HCV co-infected patients under pegylated interferon and ribavirin treatment referring to Tehran Imam Khomeini hospital during 2010 - 2013.Methods: In this descriptive cross-sectional study, all HIV/HCV co-infected patients under pegilated interferon and ribavirin treatment referring to Tehran Imam Khomeini Hospital during 2010 - 2013 entered the study. The variables include demographic information, genotype, liver involvement stage in biopsy, viral load levels prior to treatment, 4th, 12th, and 48th week as well as 6 months after treatment (sustained virologic response (SVR)), and CD4 count every 3 months.Results: In the total of 28 male HIV/HCV co-infected patients of this study, 21.4% and 78.6% received peg IFN alfa- 2b, and peg IFN alfa-2a, respectively. There were 17 genotype I (61%), 9 (32%) genotype III, and 2 (7%) genotype II among the patients. The overall SVR rate of the patients was 67.8%; it was 52.9% in genotype I and 72.7% in genotypes II and III. Despite the CD4 count decline during treatment, opportunistic infections were not observed in any of the patients Conclusions: SVR rates in this study are higher than studies conducted in other countries and this implies the possibility of a more favorable genetic trait in Iranian HCV patients responding to peg IFN and ribavirin. That is still the proper regimen due to high price of free interferon regimens in Iran.

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APA: Copy

PASHAEI ZANJANI, ALI, ESMAEILPOUR, NEGIN, RASOOLINEJAD, MEHRNAZ, MORADNEJAD, PARDIS, & HEDAYAT YAGHOOBI, MOJTABA. (2017). TREATMENT OF HEPATITIS C VIRUS INFECTION IN THE HIV- INFECTED PATIENTS BY PEGYLATED INTERFERON AND RIBAVIRIN IN TEHRAN, IRAN. AVICENNA JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTION, 4(3), 0-0. SID. https://sid.ir/paper/346866/en

Vancouver: Copy

PASHAEI ZANJANI ALI, ESMAEILPOUR NEGIN, RASOOLINEJAD MEHRNAZ, MORADNEJAD PARDIS, HEDAYAT YAGHOOBI MOJTABA. TREATMENT OF HEPATITIS C VIRUS INFECTION IN THE HIV- INFECTED PATIENTS BY PEGYLATED INTERFERON AND RIBAVIRIN IN TEHRAN, IRAN. AVICENNA JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTION[Internet]. 2017;4(3):0-0. Available from: https://sid.ir/paper/346866/en

IEEE: Copy

ALI PASHAEI ZANJANI, NEGIN ESMAEILPOUR, MEHRNAZ RASOOLINEJAD, PARDIS MORADNEJAD, and MOJTABA HEDAYAT YAGHOOBI, “TREATMENT OF HEPATITIS C VIRUS INFECTION IN THE HIV- INFECTED PATIENTS BY PEGYLATED INTERFERON AND RIBAVIRIN IN TEHRAN, IRAN,” AVICENNA JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTION, vol. 4, no. 3, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/346866/en

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