Does AUC/MIC Ratio Predict Efficacy and Safety of Vancomycin? (Review Article)

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Arasteh Omid; KHALILI HOSSEIN

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Journal Paper

Paper Information

Journal: Avicenna Journal of Clinical Microbiology and Infection Year:2019 | Volume:6 | Issue:1 Page(s): 31-42

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Information Journal Paper

Title

Does AUC/MIC Ratio Predict Efficacy and Safety of Vancomycin? (Review Article)

Author(s)

Arasteh Omid | KHALILI HOSSEIN | Issue Writer Certificate

Keywords

Vancomycin

AUC/MIC

Efficacy

Safety

Abstract

In this review, the studies in which potential correlation between the area under the curve/minimum inhibitory concentration ratio of Vancomycin (AUC/MIC) and its Efficacy and Safety had been considered, were assessed. Papers that had defined the potential correlation between Vancomycin AUC/MIC and its Efficacy, Safety, or both as a primary outcome were included. Considering that extent of Vancomycin exposure as well as susceptibility of microorganisms were both included, AUC/MIC seemed to be a more accurate index than serum trough concentration for predicting Vancomycin Efficacy. However, data regarding correlation between this index and Vancomycin-induced nephrotoxicity are limited. Different breakpoints have been defined for AUC/MIC. The optimized use of Vancomycin can improve its Efficacy and defer the occurrence of tolerance. Further studies are needed to define optimum Vancomycin AUC/MIC breakpoints and in turn predict its Efficacy and Safety.

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APA: Copy

Arasteh, Omid, & KHALILI, HOSSEIN. (2019). Does AUC/MIC Ratio Predict Efficacy and Safety of Vancomycin? (Review Article). AVICENNA JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTION, 6(1), 31-42. SID. https://sid.ir/paper/346896/en

Vancouver: Copy

Arasteh Omid, KHALILI HOSSEIN. Does AUC/MIC Ratio Predict Efficacy and Safety of Vancomycin? (Review Article). AVICENNA JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTION[Internet]. 2019;6(1):31-42. Available from: https://sid.ir/paper/346896/en

IEEE: Copy

Omid Arasteh, and HOSSEIN KHALILI, “Does AUC/MIC Ratio Predict Efficacy and Safety of Vancomycin? (Review Article),” AVICENNA JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTION, vol. 6, no. 1, pp. 31–42, 2019, [Online]. Available: https://sid.ir/paper/346896/en

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