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Information Journal Paper

Title

GALECTIN-3 SERUM LEVELS ARE INDEPENDENTLY ASSOCIATED WITH MICROALBUMINURIA IN CHRONIC HEART FAILURE OUTPATIENTS (BRIEF REPORT)

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Abstract

 Background: Galectin-3 (Gal-3) is a novel biomarker reflecting inflammation status and fibrosis involving worsening of both cardiac and renal functions.Objectives: The aim of this study was to evaluate the relationship between Gal-3 serum levels and microalbuminuria in a group of chronic HEART FAILURE (CHF) outpatients.Patients and Methods: We enrolled CHF outpatients having stable clinical conditions and receiving conventional therapy. All patients underwent clinical evaluation, routine chemistry analysis, echocardiography, and evaluation of the urinary albumin/creatinine ratio (UACR).Results: Among the patients enrolled, 61 had microalbuminuria (UACR, 30-299) and 133 normoalbuminuria (UACR,<30). Patients with normoalbuminuria showed significantly higher levels of Gal-3 than those without (19.9±8.8 vs. 14.6±5.5 ng/mL). The stepwise regression analysis indicated that Gal-3 was the first determinant of microalbuminuria (odds ratio [OR]: 1.08; 95% confidence interval [CI]: 1.02-1.14, P=0.012), followed by diabetes (OR 2.14; 95% CI: 1.00-4.57; P=0.049) and high central venous pressure (OR 2.80; 95% CI: 1.04-7.58; P= 0.042).Conclusions: Our findings indicate an independent association between Gal-3 levels and microalbuminuria, an early marker of altered renal function. This suggests the possible role of Gal-3 in the progression of cardiorenal syndrome in CHF outpatients.

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    APA: Copy

    IACOVIELLO, MASSIMO, ASPROMONTE, NADIA, LEONE, MARTA, PARADIES, VALERIA, ANTONCECCHI, VALERIA, VALLE, ROBERTO, CALDAROLA, PASQUALE, CICCONE, MARCO MATTEO, GESUALDO, LORETO, & DI SERIO, FRANCESCA. (2016). GALECTIN-3 SERUM LEVELS ARE INDEPENDENTLY ASSOCIATED WITH MICROALBUMINURIA IN CHRONIC HEART FAILURE OUTPATIENTS (BRIEF REPORT). RESEARCH IN CARDIOVASCULAR MEDICINE, 5(1), 0-0. SID. https://sid.ir/paper/346922/en

    Vancouver: Copy

    IACOVIELLO MASSIMO, ASPROMONTE NADIA, LEONE MARTA, PARADIES VALERIA, ANTONCECCHI VALERIA, VALLE ROBERTO, CALDAROLA PASQUALE, CICCONE MARCO MATTEO, GESUALDO LORETO, DI SERIO FRANCESCA. GALECTIN-3 SERUM LEVELS ARE INDEPENDENTLY ASSOCIATED WITH MICROALBUMINURIA IN CHRONIC HEART FAILURE OUTPATIENTS (BRIEF REPORT). RESEARCH IN CARDIOVASCULAR MEDICINE[Internet]. 2016;5(1):0-0. Available from: https://sid.ir/paper/346922/en

    IEEE: Copy

    MASSIMO IACOVIELLO, NADIA ASPROMONTE, MARTA LEONE, VALERIA PARADIES, VALERIA ANTONCECCHI, ROBERTO VALLE, PASQUALE CALDAROLA, MARCO MATTEO CICCONE, LORETO GESUALDO, and FRANCESCA DI SERIO, “GALECTIN-3 SERUM LEVELS ARE INDEPENDENTLY ASSOCIATED WITH MICROALBUMINURIA IN CHRONIC HEART FAILURE OUTPATIENTS (BRIEF REPORT),” RESEARCH IN CARDIOVASCULAR MEDICINE, vol. 5, no. 1, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/346922/en

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