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Information Journal Paper

Title

POLYMORPHISMS IN NOS3, MTHFR, APOB AND TNF-α GENES AND RISK OF CORONARY ATHEROSCLEROTIC LESIONS IN IRANIAN PATIENTS

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Abstract

 Background: ATHEROSCLEROSIS is a complex multifocal arterial disease involving interactions between multiple genetic and environmental factors.Objectives: In the present study, we investigated the possible association between NOS3 (rs1799983), MTHFR (rs1801133), APOB (rs5742904) and TNF-a (rs361525) POLYMORPHISMs and the risk of coronary atherosclerotic lesions in Iranian patients.Patients and Methods: In the case-control study, 108 patients with coronary ATHEROSCLEROSIS disease and 95 control subjects with no family history of cardiovascular disease were enrolled. Genotypes for NOS3, MTHFR, APOB and TNF-a POLYMORPHISMs were identified using polymerase chain reaction (PCR)-restriction fragment length POLYMORPHISM (RFLP).Results: We specifically detected the NOS3 TT genotype in 12 patients (11.11%) and did not find the same genotype in any of the controls. The frequencies of T allele in patients and the controls were 24% and 17.8%, respectively. The prevalence of the MTHFR TT genotype was 16.7% in patients and 2.2% in control groups. The prevalence of the APOB-100 (R3500Q) mutation in this patient population was 0%. The frequency of the A allele in the TNF-a gene was 11.1% and 11% in patients and controls, respectively, and the AA genotype was undetected.Conclusions: Our results show a significant association of NOS3 and MTHFR gene POLYMORPHISMs with coronary atherosclerotic lesions. Therefore, these variants might influence the risk of coronary artery disease, specifically in the Iranian population.

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    APA: Copy

    HEIDARI, MOHAMMAD MEHDI, KHATAMI, MEHRI, HADADZADEH, MEHDI, KAZEMI, MAHBOBEH, MAHAMED, SAHAR, MALEKZADEH, PEGAH, & MIRJALILI, MASSOMEH. (2016). POLYMORPHISMS IN NOS3, MTHFR, APOB AND TNF-α GENES AND RISK OF CORONARY ATHEROSCLEROTIC LESIONS IN IRANIAN PATIENTS. RESEARCH IN CARDIOVASCULAR MEDICINE, 5(1), 0-0. SID. https://sid.ir/paper/346928/en

    Vancouver: Copy

    HEIDARI MOHAMMAD MEHDI, KHATAMI MEHRI, HADADZADEH MEHDI, KAZEMI MAHBOBEH, MAHAMED SAHAR, MALEKZADEH PEGAH, MIRJALILI MASSOMEH. POLYMORPHISMS IN NOS3, MTHFR, APOB AND TNF-α GENES AND RISK OF CORONARY ATHEROSCLEROTIC LESIONS IN IRANIAN PATIENTS. RESEARCH IN CARDIOVASCULAR MEDICINE[Internet]. 2016;5(1):0-0. Available from: https://sid.ir/paper/346928/en

    IEEE: Copy

    MOHAMMAD MEHDI HEIDARI, MEHRI KHATAMI, MEHDI HADADZADEH, MAHBOBEH KAZEMI, SAHAR MAHAMED, PEGAH MALEKZADEH, and MASSOMEH MIRJALILI, “POLYMORPHISMS IN NOS3, MTHFR, APOB AND TNF-α GENES AND RISK OF CORONARY ATHEROSCLEROTIC LESIONS IN IRANIAN PATIENTS,” RESEARCH IN CARDIOVASCULAR MEDICINE, vol. 5, no. 1, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/346928/en

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