Does Opium have Benefit for Coronary Artery Disease? A Systematic Review

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Hasandokht Tolou; SALARI ARSALAN; SOLTANIPOUR SOHEIL; DADKHAH TIRANI HEIDAR; SHAD BIJAN; Rajabi Elyas

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Journal: RESEARCH IN CARDIOVASCULAR MEDICINE Year:2018 | Volume:7 | Issue:2 Page(s): 51-58

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Title

Does Opium have Benefit for Coronary Artery Disease? A Systematic Review

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Keywords

Coronary artery disease

mortality

opium

smoking

Abstract

opium is a plant with euphoria effect. People from some parts of the world traditionally use opium for cardioprotective effects. We did a systematic review to assess the effect of opium on Coronary artery disease (CAD). A systematic database search was conducted in PubMed, Web of Science, Google Scholar, Cochrane library, Scopus, and SID from their onset up to June 2016. The quality of the studies was assessed with a standardized scoring system. Articles assessing the effect of opium consumption as orally or smoked were included in this review. Outcome was deﬁ ned as age on CAD disease, risk of CAD, and morbidity from CAD. Poor methodological studies, animal studies, and studies on cardiovascular risk factors or serum markers were excluded from the review. Three case– control, three cohort, and eight crosssectional studies were included in this systematic review. The age at the occurrence of myocardial infarction, coronary bypass surgery, and percutaneous intervention in opium users was signiﬁ cantly lower than that of nonusers. Odds ratio of opium consumption for CAD ranged from 1. 3 to 3. 8 in different studies. Hazard ratio of opium consumption for ischemic heart disease was 1. 90 (1. 57– 2. 29) with modiﬁ cation by sex, ethnicity, education level, marital status, residential place, and cigarette smoking. We concluded, in spite of the traditional belief, that the current evidence did not support the protective effect of opium on CAD. Future well-designed studies concerning probable confounders in Iran and other similar parts of world are required.

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APA: Copy

Hasandokht, Tolou, SALARI, ARSALAN, SOLTANIPOUR, SOHEIL, DADKHAH TIRANI, HEIDAR, SHAD, BIJAN, & Rajabi, Elyas. (2018). Does Opium have Benefit for Coronary Artery Disease? A Systematic Review. RESEARCH IN CARDIOVASCULAR MEDICINE, 7(2), 51-58. SID. https://sid.ir/paper/347011/en

Vancouver: Copy

Hasandokht Tolou, SALARI ARSALAN, SOLTANIPOUR SOHEIL, DADKHAH TIRANI HEIDAR, SHAD BIJAN, Rajabi Elyas. Does Opium have Benefit for Coronary Artery Disease? A Systematic Review. RESEARCH IN CARDIOVASCULAR MEDICINE[Internet]. 2018;7(2):51-58. Available from: https://sid.ir/paper/347011/en

IEEE: Copy

Tolou Hasandokht, ARSALAN SALARI, SOHEIL SOLTANIPOUR, HEIDAR DADKHAH TIRANI, BIJAN SHAD, and Elyas Rajabi, “Does Opium have Benefit for Coronary Artery Disease? A Systematic Review,” RESEARCH IN CARDIOVASCULAR MEDICINE, vol. 7, no. 2, pp. 51–58, 2018, [Online]. Available: https://sid.ir/paper/347011/en

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