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Information Journal Paper

Title

ANTIBIOTIC SUSCEPTIBILITY PROFILE, ESBL PRODUCTION AND BLACTX-M1, BLA SHV AND BLATEM TYPES AMONG ESCHERICHIA COLI BLOOD ISOLATES

Pages

  9-12

Abstract

 Background: Plasmid and chromosomal extended-spectrum beta-lactamases (ESBLs) have been increasingly spread everywhere and bla CTX-M1 is one predominant beta-lactamase.Objectives: This study was fulfilled to determine the production of ESBL and prevalence of bla CTX-M1, bla SHV, and bla TEM among ESCHERICHIA COLI blood isolates in Tehran.Patients and Methods: Twenty-three isolates were adopted to be studied during 2015-2016. The antibiotic susceptibility testing was performed using Kirby–Bauer method. The combined disk method was used for the detection of phenotypic ESBL production. The most effective antibiotics were piperacillin, amikacin, and ofloxacin. The minimum inhibitory concentration (MIC) of ceftazidime was determined using micro-broth dilution method. Polymerase chain reaction (PCR) was used for detecting the bla CTX-M1, bla SHV, and bla TEM genes.Results: In the broth dilution test, 19 (82%) isolates showed MIC ³1, and 18 (78.3%) isolates were ceftazidime resistant. In the combined disk test, 19 (82%) isolates were ESBL producers. The results of the MIC and ceftazidime resistance were the same for ESBL selection. The results of MIC, in fact confirmed the disk diffusion in determining the phenotypic ESBL production. The frequency of bla CTX-M1, bla SHV, and bla TEM genes among blood ESBL producing isolates was 26% (n=6), 8.6% (n=2), and 0%, respectively. Isolates that showed higher MIC were positive for these genes.Conclusion: The prevalence of multidrug-resistant blood isolates and ESBL phenotype was high in military hospitals. A low number of blood strains amplified bla CTXM1 and bla SHV type beta–lactamases. There was a relationship between the MIC and the presence of beta-lactamase genes.

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    Cite

    APA: Copy

    NOJOOMI, FARSHAD, GHASEMIAN, ABDOLMAJID, ESLAMI, MAJID, & Khodaparast, Sepideh. (2017). ANTIBIOTIC SUSCEPTIBILITY PROFILE, ESBL PRODUCTION AND BLACTX-M1, BLA SHV AND BLATEM TYPES AMONG ESCHERICHIA COLI BLOOD ISOLATES. INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN, 5(1), 9-12. SID. https://sid.ir/paper/347487/en

    Vancouver: Copy

    NOJOOMI FARSHAD, GHASEMIAN ABDOLMAJID, ESLAMI MAJID, Khodaparast Sepideh. ANTIBIOTIC SUSCEPTIBILITY PROFILE, ESBL PRODUCTION AND BLACTX-M1, BLA SHV AND BLATEM TYPES AMONG ESCHERICHIA COLI BLOOD ISOLATES. INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN[Internet]. 2017;5(1):9-12. Available from: https://sid.ir/paper/347487/en

    IEEE: Copy

    FARSHAD NOJOOMI, ABDOLMAJID GHASEMIAN, MAJID ESLAMI, and Sepideh Khodaparast, “ANTIBIOTIC SUSCEPTIBILITY PROFILE, ESBL PRODUCTION AND BLACTX-M1, BLA SHV AND BLATEM TYPES AMONG ESCHERICHIA COLI BLOOD ISOLATES,” INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN, vol. 5, no. 1, pp. 9–12, 2017, [Online]. Available: https://sid.ir/paper/347487/en

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