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Information Journal Paper

Title

EFFECT OF MAGNETIC TACRINE-LOADED CHITOSAN NANOPARTICLES ON SPATIAL LEARNING, MEMORY, AMYLOID PRECURSOR PROTEIN AND SELADIN-1 EXPRESSION IN THE HIPPOCAMPUS OF STREPTOZOTOCIN-EXPOSED RATS

Pages

  25-31

Abstract

 ALZHEIMER’s disease (AD) is a progressive neurodegenerative disease characterized by memory and cognitive dysfunction due to neuronal cell loss in higher brain centers. Senile plaques containing amyloid b (Ab) are associated with this disease as well as a reduction in cholinergic neuron numbers. TACRINE is a reversible cholinesterase inhibitor in clinical use to treat moderate forms of AD. CHITOSAN NANOPARTICLES represent an effective systemic delivery system for drugs. The application of TACRINE-loaded CHITOSAN NANOPARTICLES has been shown to selectively increase TACRINE concentrations in the brain tissue. In this study, we compared magnetic and non-magnetic TACRINEloaded CHITOSAN NANOPARTICLES for their bioactivity and neuroprotective potency in streptozotocin (stz)-induced neurodegeneration, an accepted animal model for AD. Male rats received a single injection of stz via an implanted cannula into the lateral brain ventricle. TACRINE (tac)-loaded CHITOSAN NANOPARTICLES were delivered into the tail vein. Spatial learning and memory were analyzed using the MORRIS WATER MAZE task. Amyloid precursor protein gene (APP) and SELADIN-1 gene expression were studied in the hippocampus by real time-PCR. Tac-loaded non-magnetic and tac-loaded magnetic CHITOSAN NANOPARTICLES improved spatial learning and memory after stz treatment with magnetic NANOPARTICLES being most effective. Similarly, tac-loaded CHITOSAN NANOPARTICLES increased SELADIN-1 and reduced APP gene expression. Again, magnetic NANOPARTICLES were more effective. These data reveal that tac-loaded non magnetic and tac-loaded magneticchitosan NANOPARTICLES to a higher extent improve brain deficits related to stz application. We conclude that the magnetic target drug delivery system is a promising therapeutic strategy to protect AD-related degenerating in the CNS.

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    APA: Copy

    HASSANZADEH, GOLAMREZA, FALLAHI, ZAHRA, KHANMOHAMMADI, MOHAMMAD, ELMIZADEH, HAMIDEH, SHARIFZADEH, MOHAMMAD, NOURI, KOSAR, HEYDARIAN, ZAHRA, MAHAKIZADEH, SIMIN, ZENDEDEL, ADIB, BEYER, CORDIAN, & MOHSENI KOUCHESFAHANI, HOMA. (2016). EFFECT OF MAGNETIC TACRINE-LOADED CHITOSAN NANOPARTICLES ON SPATIAL LEARNING, MEMORY, AMYLOID PRECURSOR PROTEIN AND SELADIN-1 EXPRESSION IN THE HIPPOCAMPUS OF STREPTOZOTOCIN-EXPOSED RATS. INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL, 3(1), 25-31. SID. https://sid.ir/paper/347802/en

    Vancouver: Copy

    HASSANZADEH GOLAMREZA, FALLAHI ZAHRA, KHANMOHAMMADI MOHAMMAD, ELMIZADEH HAMIDEH, SHARIFZADEH MOHAMMAD, NOURI KOSAR, HEYDARIAN ZAHRA, MAHAKIZADEH SIMIN, ZENDEDEL ADIB, BEYER CORDIAN, MOHSENI KOUCHESFAHANI HOMA. EFFECT OF MAGNETIC TACRINE-LOADED CHITOSAN NANOPARTICLES ON SPATIAL LEARNING, MEMORY, AMYLOID PRECURSOR PROTEIN AND SELADIN-1 EXPRESSION IN THE HIPPOCAMPUS OF STREPTOZOTOCIN-EXPOSED RATS. INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL[Internet]. 2016;3(1):25-31. Available from: https://sid.ir/paper/347802/en

    IEEE: Copy

    GOLAMREZA HASSANZADEH, ZAHRA FALLAHI, MOHAMMAD KHANMOHAMMADI, HAMIDEH ELMIZADEH, MOHAMMAD SHARIFZADEH, KOSAR NOURI, ZAHRA HEYDARIAN, SIMIN MAHAKIZADEH, ADIB ZENDEDEL, CORDIAN BEYER, and HOMA MOHSENI KOUCHESFAHANI, “EFFECT OF MAGNETIC TACRINE-LOADED CHITOSAN NANOPARTICLES ON SPATIAL LEARNING, MEMORY, AMYLOID PRECURSOR PROTEIN AND SELADIN-1 EXPRESSION IN THE HIPPOCAMPUS OF STREPTOZOTOCIN-EXPOSED RATS,” INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL, vol. 3, no. 1, pp. 25–31, 2016, [Online]. Available: https://sid.ir/paper/347802/en

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