مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

DECREASED LEVEL OF THE ANTI-INFLAMMATORY ADIPOKINES, SECRETED FRIZZLED-RELATED PROTEIN 5 AND ADIPONECTIN, IN HIGH CHOLESTEROL DIET-INDUCED ATHEROSCLEROTIC RATS

Pages

  33-38

Abstract

 Introduction: The involvement of secreted frizzled-related protein 5 (SFRP5) and ADIPONECTIN, two important adipokines produced by adipocytes, in cardiovascular diseases demands further assessment. Therefore, in this study the relation of the adipokines and atherosclerosis was evaluated in RAT.Materials and methods: For the study, thirty male Wistar RATs were divided into 2 groups (each group contain 15 RATs): Control group, received a normal diet and the HIGH CHOLESTEROL DIET (HCD) group which received an additional 2% cholesterol and 0.5% cholic acid for 15 weeks. At the end of treatment, HCD-induced ATHEROSCLEROTIC PLAQUEs were observed by hematoxylin and eosin staining of aortic tissue sections. Furthermore, serum levels of SFRP5 and ADIPONECTIN in the two groups of RATs were measured by immunoassay and their relationships with the development of ATHEROSCLEROTIC PLAQUEs in the animals were analyzed.Results: The serum level of SFRP5 and ADIPONECTIN was significantly decreased in HCD RATs compared with the control group (P<0.05). There was also an inverse relation between the serum level of the two adipokines and ATHEROSCLEROTIC PLAQUE formation (P<0.05).Conclusion: Serum levels of SFRP5 and ADIPONECTIN are decreased in RATs fed with HIGH CHOLESTEROL DIET, highlighting the involvement of the two adipokines in atherosclerosis.

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    APA: Copy

    GHARIBI, AGHDAS, YAGHMAEI, PARICHEHR, BASATI, GHOLAM, SOLEIMANNEJAD, KOUROSH, & ABBASI, NASER. (2018). DECREASED LEVEL OF THE ANTI-INFLAMMATORY ADIPOKINES, SECRETED FRIZZLED-RELATED PROTEIN 5 AND ADIPONECTIN, IN HIGH CHOLESTEROL DIET-INDUCED ATHEROSCLEROTIC RATS. JOURNALS OF BASIC RESEARCH IN MEDICAL SCIENCES, 5(2), 33-38. SID. https://sid.ir/paper/348509/en

    Vancouver: Copy

    GHARIBI AGHDAS, YAGHMAEI PARICHEHR, BASATI GHOLAM, SOLEIMANNEJAD KOUROSH, ABBASI NASER. DECREASED LEVEL OF THE ANTI-INFLAMMATORY ADIPOKINES, SECRETED FRIZZLED-RELATED PROTEIN 5 AND ADIPONECTIN, IN HIGH CHOLESTEROL DIET-INDUCED ATHEROSCLEROTIC RATS. JOURNALS OF BASIC RESEARCH IN MEDICAL SCIENCES[Internet]. 2018;5(2):33-38. Available from: https://sid.ir/paper/348509/en

    IEEE: Copy

    AGHDAS GHARIBI, PARICHEHR YAGHMAEI, GHOLAM BASATI, KOUROSH SOLEIMANNEJAD, and NASER ABBASI, “DECREASED LEVEL OF THE ANTI-INFLAMMATORY ADIPOKINES, SECRETED FRIZZLED-RELATED PROTEIN 5 AND ADIPONECTIN, IN HIGH CHOLESTEROL DIET-INDUCED ATHEROSCLEROTIC RATS,” JOURNALS OF BASIC RESEARCH IN MEDICAL SCIENCES, vol. 5, no. 2, pp. 33–38, 2018, [Online]. Available: https://sid.ir/paper/348509/en

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