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Title

COMPARISON OF PFHRP-2/PLDH RDTS WITH LIGHT MICROSCOPY IN A LOW PREVALENCE SETTING IN SOUTHEASTERN IRAN, SISTAN AND BALUCHESTAN: DUE TO IMPLEMENTATION OF MALARIA ELIMINATION PROGRAM

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Abstract

 Background: The gold standard for diagnosing MALARIA in IRAN is using LIGHT MICROSCOPY; however, this method requires equipment, time and skilled microscopists. In some circumstances, rapid diagnostic test (RDTs) can be a proper substitute. Assessing the diagnostic performance of RDT relative to microscopy, for the diagnosis of MALARIA in Southeastern IRAN, Sistan and Baluchestan, was the purpose of this study.Methods: From March to July 2016, which was a peak transmission season in IRAN, 318 patients with suspected MALARIA were taken for a blood sample at the health center in Saravan, in Sistan and Baluchestan Province. The samples were surveyed instantly by LIGHT MICROSCOPY and RDT. Comparison analysis included: sensitivity, specificity, positive and negative predictive values, and other diagnostic screening performance measures for detecting MALARIA infections.Results: Of the 318 MALARIA cases (6.6%), 21 were identified by a microscopy compared to 22 of 318 (6.9%) by RDT. RDT sensitivity and specificity for the diagnosis of MALARIA were 95.5% (77.2% - 99.9%, 95% CI) and 100% (98.8% - 100%, 95% CI), respectively, compared to standard microscopy, the sensitivity and specificity forvivax MALARIA were 100% (79.4-100%, 95% CI) and 99.7% (98.14% - 99.99%, 95% CI), and forfalciparum MALARIA: 80% (28.4% - 99.5%, 95% CI) and 100% (98.8% - 100%, 95% CI). Two tests showed an amazing agreement with a kappa estimation of 0.975.Conclusions: The study proved that the RDT test performs appropriately for the identification of infections with P. falciparum and P. vivaxMALARIA in cross-border MALARIA. Moreover, the RDT can be a useful instrument for the identification of new clinical cases of MALARIA in this region.

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    APA: Copy

    RAHMATI BALAGHALEH, MANSOUR, Zarean, Mehdi, AFZALAGHAEE, MONNAVAR, SHAMSIAN, SEYYED ALI AKBAR, MIRAHMADI, HADI, & ARYA, ARSLAAN. (2018). COMPARISON OF PFHRP-2/PLDH RDTS WITH LIGHT MICROSCOPY IN A LOW PREVALENCE SETTING IN SOUTHEASTERN IRAN, SISTAN AND BALUCHESTAN: DUE TO IMPLEMENTATION OF MALARIA ELIMINATION PROGRAM. INTERNATIONAL JOURNAL OF INFECTION, 5(1), 0-0. SID. https://sid.ir/paper/349157/en

    Vancouver: Copy

    RAHMATI BALAGHALEH MANSOUR, Zarean Mehdi, AFZALAGHAEE MONNAVAR, SHAMSIAN SEYYED ALI AKBAR, MIRAHMADI HADI, ARYA ARSLAAN. COMPARISON OF PFHRP-2/PLDH RDTS WITH LIGHT MICROSCOPY IN A LOW PREVALENCE SETTING IN SOUTHEASTERN IRAN, SISTAN AND BALUCHESTAN: DUE TO IMPLEMENTATION OF MALARIA ELIMINATION PROGRAM. INTERNATIONAL JOURNAL OF INFECTION[Internet]. 2018;5(1):0-0. Available from: https://sid.ir/paper/349157/en

    IEEE: Copy

    MANSOUR RAHMATI BALAGHALEH, Mehdi Zarean, MONNAVAR AFZALAGHAEE, SEYYED ALI AKBAR SHAMSIAN, HADI MIRAHMADI, and ARSLAAN ARYA, “COMPARISON OF PFHRP-2/PLDH RDTS WITH LIGHT MICROSCOPY IN A LOW PREVALENCE SETTING IN SOUTHEASTERN IRAN, SISTAN AND BALUCHESTAN: DUE TO IMPLEMENTATION OF MALARIA ELIMINATION PROGRAM,” INTERNATIONAL JOURNAL OF INFECTION, vol. 5, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/349157/en

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