مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

257
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

172
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

STUDY OF ASSOCIATION BETWEEN TLR4 D299G AND T399I POLYMORPHISMS AND RISK OF GASTRIC CANCER

Pages

  16-22

Abstract

 Introduction: Gastrointestinal cancers constitute more than one-third of the most common cancers and half of the fatal cancers worldwide. Toll-like receptors (TLRs) are identified as pivotal receptors in innate immunity responses. TLR4 is the main receptor that plays a role in lipopolysaccharide (LPS) sensing of gram-positive bacteria. D299G (rs4986790) and T399I (rs4986791) POLYMORPHISMs in TLR4 lead to a decrease in immune response against LPS. The current study aimed at investigating the relationship between D299G and T399I POLYMORPHISMs and susceptibility to gastritis and gastric precancerous lesions in patients referred to Imam Reza Hospital, Tehran, Iran.Methods: The current case-control study was conducted on 201 individuals consisting of 90 patients with gastric cancer (GC) and 111 healthy controls. Genomic DNA was extracted from peripheral blood and the polymerase chain reaction-restriction fragment length POLYMORPHISM (PCR-RFLP) method was used to determine the mentioned POLYMORPHISMs. Results: Allelic frequencies and genetic distribution of POLYMORPHISMs were analyzed in the patient and control groups. Although 399C and 299A allele frequencies were higher in the patients` group, the difference was not statistically significant (P>0.05).Conclusions: No significant association was observed between TLR4 POLYMORPHISMs on positions 299 and 399, and susceptibility to GC. Also no significant correlation was observed between these two POLYMORPHISMs and precancerous lesions. The current study results showed that the studied POLYMORPHISMs cannot be used as a prognostic marker of GC in Iranian population.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    HATAMI, HASAN, NAGHOOSI, HAMED, NOURIAN, MAHYAR, IRANPOUR, MOSTAFA, SAIDI, SANDRA, HASHEMI, MAHMOUD REZA, & IRAVANI, SHAHROKH. (2018). STUDY OF ASSOCIATION BETWEEN TLR4 D299G AND T399I POLYMORPHISMS AND RISK OF GASTRIC CANCER. MULTIDISCIPLINARY CANCER INVESTIGATION, 2(3), 16-22. SID. https://sid.ir/paper/349700/en

    Vancouver: Copy

    HATAMI HASAN, NAGHOOSI HAMED, NOURIAN MAHYAR, IRANPOUR MOSTAFA, SAIDI SANDRA, HASHEMI MAHMOUD REZA, IRAVANI SHAHROKH. STUDY OF ASSOCIATION BETWEEN TLR4 D299G AND T399I POLYMORPHISMS AND RISK OF GASTRIC CANCER. MULTIDISCIPLINARY CANCER INVESTIGATION[Internet]. 2018;2(3):16-22. Available from: https://sid.ir/paper/349700/en

    IEEE: Copy

    HASAN HATAMI, HAMED NAGHOOSI, MAHYAR NOURIAN, MOSTAFA IRANPOUR, SANDRA SAIDI, MAHMOUD REZA HASHEMI, and SHAHROKH IRAVANI, “STUDY OF ASSOCIATION BETWEEN TLR4 D299G AND T399I POLYMORPHISMS AND RISK OF GASTRIC CANCER,” MULTIDISCIPLINARY CANCER INVESTIGATION, vol. 2, no. 3, pp. 16–22, 2018, [Online]. Available: https://sid.ir/paper/349700/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button