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Information Journal Paper

Title

Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognostic Markers

Pages

  16-24

Abstract

 Introduction: Bovine Leukemia Virus (BLV) causes enzootic bovine leukemia, and is closely related to human T-lymphotropic virus type 1. It expresses microRNAs of unknown function and codes Tax, the protein that mediates malignant transformation. BLV is capable of infecting B-and T-lymphocytes, endothelial cells, and mammary epithelial cells of cattle. Several studies demonstrated the presence of BLV DNA in human tissue, and it is significantly associated with breast cancer in case-control studies using in situ Polymerase Chain Reaction (PCR), a highly sensitive and specific technique. The current study was the first report of BLV DNA detection by in situ PCR in tissue from Argentinian females with a diagnosis of breast cancer. Methods: In situ PCR was done to detect BLV DNA in 85 human FFPE breast cancer tissue samples. The association of BLV DNA and expression of Ki67 and Her-2 was assessed. Results: BLV DNA presence could be determined in 22. 6% of the analyzed samples, and its presence was associated with an increase of the expression and prognostic markers Ki67 (P=0. 009) and HER-2 (P=0. 044) determined by conventional immunohistochemistry. No statistical significance was observed between the presence or absence of hormonal receptors and the presence of BLV DNA. Conclusions: The obtained results support the idea that BLV might play a role in malignant tissue transformation.

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    APA: Copy

    Lendez, Pamela Anahi, Cuesta, Lucia Martinez, Nieto Farias, Maria Victoria, Shen, Hua Min, Dolcini, Guillermina Laura, Buehring, Gertrude Case, & Ceriani, Maria Carolina. (2018). Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognostic Markers. MULTIDISCIPLINARY CANCER INVESTIGATION, 2(4), 16-24. SID. https://sid.ir/paper/349713/en

    Vancouver: Copy

    Lendez Pamela Anahi, Cuesta Lucia Martinez, Nieto Farias Maria Victoria, Shen Hua Min, Dolcini Guillermina Laura, Buehring Gertrude Case, Ceriani Maria Carolina. Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognostic Markers. MULTIDISCIPLINARY CANCER INVESTIGATION[Internet]. 2018;2(4):16-24. Available from: https://sid.ir/paper/349713/en

    IEEE: Copy

    Pamela Anahi Lendez, Lucia Martinez Cuesta, Maria Victoria Nieto Farias, Hua Min Shen, Guillermina Laura Dolcini, Gertrude Case Buehring, and Maria Carolina Ceriani, “Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognostic Markers,” MULTIDISCIPLINARY CANCER INVESTIGATION, vol. 2, no. 4, pp. 16–24, 2018, [Online]. Available: https://sid.ir/paper/349713/en

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