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Information Journal Paper

Title

The Effect of N-Acetylcysteine Administration to Prevent Anthracycline-Induced Cardiotoxicity in Breast Cancer Patients

Pages

  16-19

Abstract

 Introduction: Anthracyclines are one of the classes of chemotherapy drugs that are widely used to treat many types of cancers including Breast Cancer. Taking this class of medications has a significant relationship with cardiac dysfunction. N-Acetylcysteine has antioxidant properties and may be effective in preventing cardiac dysfunctions. In this study, we investigated the effect of N-Acetylcysteine in preventing Cardiotoxicity in Breast Cancer patients receiving anthracycline. Methods: A total of 60 Breast Cancer patients who underwent chemotherapy with Anthracyclines were enrolled in the present case-control study and divided into two groups. The case group received 600 mg of N-Acetylcysteine per day adjacent to chemotherapy; while the control group did not receive this medication. One month after the last chemotherapy session, troponin I was measured as a predictor of Cardiotoxicity. Results: Troponin I was positive in one patient in the case group compared with 3 patients in the control group without any significant difference among groups (P> 0. 05) However, the respective mean± SD level of troponin I was 0. 120± 0. 039 and 0. 192± 0. 063 in the case and control groups with a statistically significant difference among groups (P <0. 001). Conclusions: Administration of 600 mg N-Acetylcysteine per day during the anthracyclinebased chemotherapy protocol in Breast Cancer patients may reduce the mean troponin I levels which can be a prediction of reduced Anthracyclines Cardiotoxicity.

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    Cite

    APA: Copy

    Khazdooz, Hamid, NOURIAN, MAHYAR, JALAEIKHOO, HASAN, RAJAEINEJAD, MOHSEN, Johari Moghadam, Adel, IRANPOUR, MOSTAFA, NAGHOOSI, HAMED, & TOFANGCHIHA, SHAHNAZ. (2019). The Effect of N-Acetylcysteine Administration to Prevent Anthracycline-Induced Cardiotoxicity in Breast Cancer Patients. MULTIDISCIPLINARY CANCER INVESTIGATION, 3(3), 16-19. SID. https://sid.ir/paper/349725/en

    Vancouver: Copy

    Khazdooz Hamid, NOURIAN MAHYAR, JALAEIKHOO HASAN, RAJAEINEJAD MOHSEN, Johari Moghadam Adel, IRANPOUR MOSTAFA, NAGHOOSI HAMED, TOFANGCHIHA SHAHNAZ. The Effect of N-Acetylcysteine Administration to Prevent Anthracycline-Induced Cardiotoxicity in Breast Cancer Patients. MULTIDISCIPLINARY CANCER INVESTIGATION[Internet]. 2019;3(3):16-19. Available from: https://sid.ir/paper/349725/en

    IEEE: Copy

    Hamid Khazdooz, MAHYAR NOURIAN, HASAN JALAEIKHOO, MOHSEN RAJAEINEJAD, Adel Johari Moghadam, MOSTAFA IRANPOUR, HAMED NAGHOOSI, and SHAHNAZ TOFANGCHIHA, “The Effect of N-Acetylcysteine Administration to Prevent Anthracycline-Induced Cardiotoxicity in Breast Cancer Patients,” MULTIDISCIPLINARY CANCER INVESTIGATION, vol. 3, no. 3, pp. 16–19, 2019, [Online]. Available: https://sid.ir/paper/349725/en

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