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Information Journal Paper

Title

Chromosomal Rearrangements of RET/PTC in Post-Chernobyl Thyroid Cancer

Pages

  28-35

Abstract

 A hypothesis is proposed here that RET rearrangements in papillary thyroid cancers are related to the disease duration and tumor progression. The most common RET rearrangements are RET/PTC1 and RET/PTC3. RET/PTC1 is more prevalent in classic papillary thyroid carcinoma (PTC), its diffuse sclerosing variant, and papillary microcarcinoma; while RET/PTC3 is frequently found in less differentiated solid PTC. RET/PTC3 is associated with larger tumor size and multifocality in sporadic pediatric PTC. The RET rearrangements; especially RET/PTC3, which is frequently detected among Chernobyl thyroid cancers is developed after exposure to Radiation at an early age, is proposed to be a potential trigger of malignancy. There are many late-stage tumors among the first-wave Chernobyl PTCs that tend to be larger and less differentiated than those detected later. The high proportion of late-stage cases shortly after the accident is explained by the neglected cases in the screening process and also by the fact that some non-exposed patients were registered as Radiation-exposed. The screening was productive because of the reservoir of undiagnosed cases in the population: registered incidence of thyroid cancer (TC) among children and adolescents prior to the Chernobyl disaster was low in the Soviet Union; compared to other developed countries. In conclusion, RET rearrangements, especially RET/PTC3, were correlated with the tumor progression. If the hypothesis defended here is correct, a low prevalence of RET/PTC3 among sporadic TC is circumstantial evidence of efficient cancer diagnosis and early detection.

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    Cite

    APA: Copy

    JARGIN, SERGEI V.. (2020). Chromosomal Rearrangements of RET/PTC in Post-Chernobyl Thyroid Cancer. MULTIDISCIPLINARY CANCER INVESTIGATION, 4(2), 28-35. SID. https://sid.ir/paper/349737/en

    Vancouver: Copy

    JARGIN SERGEI V.. Chromosomal Rearrangements of RET/PTC in Post-Chernobyl Thyroid Cancer. MULTIDISCIPLINARY CANCER INVESTIGATION[Internet]. 2020;4(2):28-35. Available from: https://sid.ir/paper/349737/en

    IEEE: Copy

    SERGEI V. JARGIN, “Chromosomal Rearrangements of RET/PTC in Post-Chernobyl Thyroid Cancer,” MULTIDISCIPLINARY CANCER INVESTIGATION, vol. 4, no. 2, pp. 28–35, 2020, [Online]. Available: https://sid.ir/paper/349737/en

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