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Information Journal Paper

Title

Effect of Chelation Therapy on Lead-induced Hepatotoxicity: A Case Series

Pages

  159-164

Abstract

 Background: Opium use is one of the common causes of lead toxicity. Lead poisoning can lead to hepatic, hematologic, musculoskeletal, neurological, and cardiovascular damages. In this study, we investigated the reversibility of lead-induced liver damage following Chelation therapy. Methods: We reviewed the medical records of patients with opium-induced Lead poisoning regarding elevation in hepatobiliary enzymes level including Alanine Transaminase (ALT), Aspartate Transaminase (AST), and Alkaline Phosphatase (ALP) to normal level and recorded patients’ age, treatment regimen, liver enzymes level before and after treatment; we also investigated other laboratory findings to rule out other causes of liver enzymes increase. Results: We evaluated 10 male patients with the mean age of 48. 3± 7. 42 years. All patients were referred with the chief complain of abdominal cramps (100%). The mean lead level in patients was 84. 48± 9. 95 μ g/dL. The mean serum levels of ALT, AST, and ALP significantly decreased after the treatment with chelating agents ([ALT=117. 8± 60. 22μ g/dL-76. 9± 40. 73μ g/ dL, P=0. 022], [AST=100. 9± 63. 96μ g/dL-69. 9± 37. 41μ g/dL, P=0. 028], [ALP=449. 8± 234. 81 μ g/dL-338. 3± 131. 22μ g/dL, P=0. 037]). There was no significant correlation between patients’ lead level and liver enzymes level before and after the treatment. Conclusion: The results of this study showed that the treatment with chelating agents reverses the liver injury following the lead intoxication.

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    APA: Copy

    Shadfar, Faezeh, ZAKARIAEI, ZAKARIA, Ghasempoori, Seyed Khosro, MOOSAZADEH, MAHMOOD, & KHOSRAVI, NAVID. (2019). Effect of Chelation Therapy on Lead-induced Hepatotoxicity: A Case Series. INTERNATIONAL JOURNAL OF MEDICAL TOXICOLOGY AND FORENSIC MEDICINE, 9(3), 159-164. SID. https://sid.ir/paper/350679/en

    Vancouver: Copy

    Shadfar Faezeh, ZAKARIAEI ZAKARIA, Ghasempoori Seyed Khosro, MOOSAZADEH MAHMOOD, KHOSRAVI NAVID. Effect of Chelation Therapy on Lead-induced Hepatotoxicity: A Case Series. INTERNATIONAL JOURNAL OF MEDICAL TOXICOLOGY AND FORENSIC MEDICINE[Internet]. 2019;9(3):159-164. Available from: https://sid.ir/paper/350679/en

    IEEE: Copy

    Faezeh Shadfar, ZAKARIA ZAKARIAEI, Seyed Khosro Ghasempoori, MAHMOOD MOOSAZADEH, and NAVID KHOSRAVI, “Effect of Chelation Therapy on Lead-induced Hepatotoxicity: A Case Series,” INTERNATIONAL JOURNAL OF MEDICAL TOXICOLOGY AND FORENSIC MEDICINE, vol. 9, no. 3, pp. 159–164, 2019, [Online]. Available: https://sid.ir/paper/350679/en

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