مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

INTRANASAL KETAMINE ADMINISTRATION FOR NARCOTIC DOSE DECREMENT IN PATIENTS SUFFERING FROM ACUTE LIMB TRAUMA IN EMERGENCY DEPARTMENT: A DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED TRIAL

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Abstract

 Introduction: PAIN MANAGEMENT is an important and challenging issue in EMERGENCY MEDICINE. Despite the conduct of several studies on this topic, pain is still handled improperly in many cases.Objective: This study investigated the effectiveness of low-dose IN KETAMINE administration in reducing the need for opiates in patients in acute pain resulting from limb injury.Method: This randomized, double-blind, placebo-controlled trial was conducted to assess the possible effect of low-dose intranasal (IN) KETAMINE administration in decreasing patients' narcotic need. Patients in emergency department suffering from acute isolated limb trauma were included. One group of patients received 0.5 mg/kg intravenous MORPHINE sulfate and 0.02 ml/kg IN KETAMINE. The other group received the same dose of MORPHINE sulfate and 0.02 ml/kg IN distilled water. Pain severity was measured using the 11 points numerical rating scale at 0, 10, 30, 60, 120, and 180 minutes.Results: Ninety-one patients with mean age of 31.62 ± 9.13 years were enrolled (54.9% male). The number of requests for supplemental medication was significantly lower in patients who received KETAMINE (12 patients (30%)) than those who received placebo (27 patients (67.5%)) (p=0.001).Conclusion: It is likely that low-dose IN KETAMINE is effective in reducing the narcotic need of patients suffering from acute limb trauma.

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    APA: Copy

    MOHAMMADSHAHI, ALI, ABDOLRAZAGHNEJAD, ALI, NIKZAMIR, HAMED, & SAFAIE, ARASH. (2018). INTRANASAL KETAMINE ADMINISTRATION FOR NARCOTIC DOSE DECREMENT IN PATIENTS SUFFERING FROM ACUTE LIMB TRAUMA IN EMERGENCY DEPARTMENT: A DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED TRIAL. (FRONTIERS IN EMERGENCY MEDICINE) ADVANCED JOURNAL OF EMERGENCY MEDICINE, 2(3), 0-0. SID. https://sid.ir/paper/351057/en

    Vancouver: Copy

    MOHAMMADSHAHI ALI, ABDOLRAZAGHNEJAD ALI, NIKZAMIR HAMED, SAFAIE ARASH. INTRANASAL KETAMINE ADMINISTRATION FOR NARCOTIC DOSE DECREMENT IN PATIENTS SUFFERING FROM ACUTE LIMB TRAUMA IN EMERGENCY DEPARTMENT: A DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED TRIAL. (FRONTIERS IN EMERGENCY MEDICINE) ADVANCED JOURNAL OF EMERGENCY MEDICINE[Internet]. 2018;2(3):0-0. Available from: https://sid.ir/paper/351057/en

    IEEE: Copy

    ALI MOHAMMADSHAHI, ALI ABDOLRAZAGHNEJAD, HAMED NIKZAMIR, and ARASH SAFAIE, “INTRANASAL KETAMINE ADMINISTRATION FOR NARCOTIC DOSE DECREMENT IN PATIENTS SUFFERING FROM ACUTE LIMB TRAUMA IN EMERGENCY DEPARTMENT: A DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED TRIAL,” (FRONTIERS IN EMERGENCY MEDICINE) ADVANCED JOURNAL OF EMERGENCY MEDICINE, vol. 2, no. 3, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/351057/en

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