Comparing the Therapeutic Effects of Dexamethasone-Metoclopramide with Ketorolac in Relieving Headache in Patients with Acute Migraine Attacks Presenting to the Emergency Department

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TALEBIAN MOHAMMAD TAGHI; MIRBAHA SAHAR; DAVARINEZHAD MOGHADAM ELNAZ; PAYANDEMEHR POOYA

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Journal Paper

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Journal: Frontiers in Emergency Medicine Year:2019 | Volume:3 | Issue:2 Page(s): 0-0

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Title

Comparing the Therapeutic Effects of Dexamethasone-Metoclopramide with Ketorolac in Relieving Headache in Patients with Acute Migraine Attacks Presenting to the Emergency Department

Author(s)

TALEBIAN MOHAMMAD TAGHI | MIRBAHA SAHAR | DAVARINEZHAD MOGHADAM ELNAZ | PAYANDEMEHR POOYA | Issue Writer Certificate

Keywords

Dexamethasone

Emergency Department

Hospital

Ketorolac

Metoclopramide

Migraine Disorders

Pain Management

Abstract

Introduction: Migraine is a frequent chief complaint of patients in the Emergency Department. A wide range of treatments are used for acute migraine. Objective: This study aimed to compare the therapeutic effects of a combination of Metoclopramide + Dexamethasone with those of Ketorolac for treatment of acute migraine in the Emergency Department. Method: This quasi-experimental study enrolled patients identified as migraine headache cases admitted to the Emergency Departments of Shohadaye Tajrish and Sina Hospitals, Tehran, Iran. The patients were divided into two groups and treated with either 8 mg Dexamethasone + 10 mg Metoclopramide or 60 mg Ketorolac, and then compared regarding the rate of pain control based on visual analogue scale (VAS) on arrival and 1 and 2 hours afterward. Results: Overall, 86 patients were recruited, of whom 50 were male (58. 1%). Their mean age was 37. 6 ± 10. 3 years. Thirty-five (40. 7%) were in the Ketorolac group and 51 (59. 3%) were in the Dexamethasone + Metoclopramide group. Treatment success was defined as a reduction of at least 3 points in pain severity in comparison to the admission time. One hour after administration of medications, the reported pain intensity was 4. 7 ± 2. 0 and 6. 2 ± 2. 3 in Ketorolac group and Dexamethasone + Metoclopramide group, respectively. By the second hour, pain intensity was 3. 4 ± 1. 2 and 2. 9 ± 1. 3 in Ketorolac group and Dexamethasone + Metoclopramide group, respectively. The two groups did not show a significant difference in terms of the reported pain at this time (p= 0. 04). Conclusion: Based on our findings, the pain reduction time was relatively shorter for Ketorolac in acute migraine, but the final response was identical in the two groups.

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APA: Copy

TALEBIAN, MOHAMMAD TAGHI, MIRBAHA, SAHAR, DAVARINEZHAD MOGHADAM, ELNAZ, & PAYANDEMEHR, POOYA. (2019). Comparing the Therapeutic Effects of Dexamethasone-Metoclopramide with Ketorolac in Relieving Headache in Patients with Acute Migraine Attacks Presenting to the Emergency Department. (FRONTIERS IN EMERGENCY MEDICINE) ADVANCED JOURNAL OF EMERGENCY MEDICINE, 3(2), 0-0. SID. https://sid.ir/paper/351085/en

Vancouver: Copy

TALEBIAN MOHAMMAD TAGHI, MIRBAHA SAHAR, DAVARINEZHAD MOGHADAM ELNAZ, PAYANDEMEHR POOYA. Comparing the Therapeutic Effects of Dexamethasone-Metoclopramide with Ketorolac in Relieving Headache in Patients with Acute Migraine Attacks Presenting to the Emergency Department. (FRONTIERS IN EMERGENCY MEDICINE) ADVANCED JOURNAL OF EMERGENCY MEDICINE[Internet]. 2019;3(2):0-0. Available from: https://sid.ir/paper/351085/en

IEEE: Copy

MOHAMMAD TAGHI TALEBIAN, SAHAR MIRBAHA, ELNAZ DAVARINEZHAD MOGHADAM, and POOYA PAYANDEMEHR, “Comparing the Therapeutic Effects of Dexamethasone-Metoclopramide with Ketorolac in Relieving Headache in Patients with Acute Migraine Attacks Presenting to the Emergency Department,” (FRONTIERS IN EMERGENCY MEDICINE) ADVANCED JOURNAL OF EMERGENCY MEDICINE, vol. 3, no. 2, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/351085/en

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