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Information Journal Paper

Title

BETAINE IMPROVES GASTROPROTECTIVE EFFECTS OF RANITIDINE AND OMEPRAZOLE AGAINST INDOMETHACIN-INDUCED GASTRIC ULCER IN RATS

Pages

  9-17

Abstract

 Background and Aim: Antioxidant capacity of BETAINE has been indicated in our recent studies. Thus, we examined oral BETAINE as an antioxidant agent in combination with antisecretory drugs to prevent INDOMETHACIN-induced gastric damages in RATs.Materials and Methods: Fifty-six adult male Sprague-Dawley RATs were divided into two controls (negative and normal) and five experimental groups as follows: BETAINE-indomethacin (Bet.-Ind.), ascorbic acid-indomethacin (Asc.-Ind.), OMEPRAZOLE-indomethacin (Ome.-Ind.), BETAINE-omeprazole plus INDOMETHACIN (Bet.-Ome.-Ind.) and BETAINE-ranitidine plus INDOMETHACIN (Bet.-Ran.-Ind.).Results: The BETAINE pretreated groups received BETAINE at a dosage of 1.5% (w/w) in their diet, whereas 50 mg/kg of ascorbic acid was administered orally to the Asc.-Ind., group for 15 consecutive days. After a 24 hour fast, all the groups received 48 mg/kg of INDOMETHACIN once except for normal control group. The OMEPRAZOLE and RANITIDINE groups also received one dose of OMEPRAZOLE (10 mg/kg) and RANITIDINE (50 mg/kg), 120 minutes before receiving INDOMETHACIN. Histopathological findings indicated the gastroprotective effects of BETAINE and RANITIDINE in pretreated RATs. Pretreatment by BETAINE and RANITIDINE increased significantly the ULCER index inhibition (%), in comparison with ascorbic acid and OMEPRAZOLE (alone) treatment. Glutathione peroxidase (GPx) activity was significantly higher in the Bet.-Ran.-Ind., group as compared to the Asc.-Ind., and Ome.-Ind., treated RATs. GPx activity also increased significantly in Bet.-Ind., treated RATs as compared to the Asc.-Ind. group. Catalase (CAT) activity was remarkably higher in the Bet.-Ran.-Ind., treated RATs than the Asc.-Ind., and Ome.-Ind., groups. TBARS concentration as a lipid peroxidation marker increased significantly in Ome.-Ind., group as compared to the Bet.-Ind., and Bet.-Ran.-Ind., treated RATs.Conclusion: Thus, it seems that BETAINE as an antioxidant agent, is able to improve the effects of RANITIDINE and OMEPRAZOLE against INDOMETHACIN-mediated gastric damages in RATs. It may also be promising in the prevention of NSAIDs side effects.

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    APA: Copy

    ALIREZAEI, MASOUD, JALDANI, VAHID, DEZFOULIAN, OMID, & SHAHSAVARI, GHOLAMREZA. (2017). BETAINE IMPROVES GASTROPROTECTIVE EFFECTS OF RANITIDINE AND OMEPRAZOLE AGAINST INDOMETHACIN-INDUCED GASTRIC ULCER IN RATS. HERBAL MEDICINES JOURNAL, 2(1 ), 9-17. SID. https://sid.ir/paper/351282/en

    Vancouver: Copy

    ALIREZAEI MASOUD, JALDANI VAHID, DEZFOULIAN OMID, SHAHSAVARI GHOLAMREZA. BETAINE IMPROVES GASTROPROTECTIVE EFFECTS OF RANITIDINE AND OMEPRAZOLE AGAINST INDOMETHACIN-INDUCED GASTRIC ULCER IN RATS. HERBAL MEDICINES JOURNAL[Internet]. 2017;2(1 ):9-17. Available from: https://sid.ir/paper/351282/en

    IEEE: Copy

    MASOUD ALIREZAEI, VAHID JALDANI, OMID DEZFOULIAN, and GHOLAMREZA SHAHSAVARI, “BETAINE IMPROVES GASTROPROTECTIVE EFFECTS OF RANITIDINE AND OMEPRAZOLE AGAINST INDOMETHACIN-INDUCED GASTRIC ULCER IN RATS,” HERBAL MEDICINES JOURNAL, vol. 2, no. 1 , pp. 9–17, 2017, [Online]. Available: https://sid.ir/paper/351282/en

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