HEARING LOSS: A REVIEW ON MOLECULAR GENETICS AND EPIDEMIOLOGIC ASPECTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

karami eshkaftaki Razieh; AHMADINEJAD FERESHTEH; AGHAEI SHAHRZAD; Moghim Hassan; HASHEMZADEH CHALESHTORI MORTEZA; Jami Mohammad Saeid

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Epidemiology and Health System Journal Year:2017 | Volume:4 | Issue:2 Page(s): 166-172

Download Full-Text

View:

195

Download:

Cites:

Information Journal Paper

Title

HEARING LOSS: A REVIEW ON MOLECULAR GENETICS AND EPIDEMIOLOGIC ASPECTS

Author(s)

Keywords

HEARING LOSS

IRANIAN POPULATION

GJB2

Abstract

Background and aims: HEARING LOSS (HL) happens due to the genetic or environmental causes or both. Risk factors include congenital infections and congenital deformities of auricle and ear duct. The present study was performed to briefly explain the genetics, molecular biology and epidemiology of HL in Middle East especially in Iran.Methods: An intense an comprehensive literature search was prformed through heading journals in the field. All data was organized using Mendeley software and incorporated to the text as required.Results: While the etiology of 25% of HL cases remains indistinct, it is estimated that at least 50% of pre lingual HL cases have a genetic cause. About 70% of genetic HL cases are non Syndromic (NSHL) without anomaly, whereas the remaining 30% are Syndromic. Autosomal recessive non-syndromic HEARING LOSS forms (ARNSHL) are the severest forms of congenital HL with defect in cochlea. In addition to X-linked (DFNX), autosomal dominant (DFNA), autosomal recessive (DFNB) and Y-linked (DFNY) inheritance patterns, HL can be inherited through mitochondrial genes including MT-RNR1 and MT-TS. At least 120 genes have been reported to be associated with HL. Among them, mutations in connexin 26 (GJB2) have been shown to play a very important role in developing ARSNSHL in many populations depending on geographical location and ethnicity. In Caucasians and Spainish/Italian populations, 50% and 79% of HL cases have respectively been reported to be occurred due to mutations in GJB2 gene.Conclusion: In the Middle East, the prevalence seems different as an average of 14-20% of the HL in several region of Iran is due to mutation in GJB2 gene. Alternatively similar studies showed the prevalence of GJB2 mutations around 25% and 6.1% in Turkey and Pakistani populations respectively.

Cites

References

No record.

Cite

APA: Copy

karami eshkaftaki, Razieh, AHMADINEJAD, FERESHTEH, AGHAEI, SHAHRZAD, Moghim, Hassan, HASHEMZADEH CHALESHTORI, MORTEZA, & Jami, Mohammad Saeid. (2017). HEARING LOSS: A REVIEW ON MOLECULAR GENETICS AND EPIDEMIOLOGIC ASPECTS. EPIDEMIOLOGY AND HEALTH SYSTEM JOURNAL (INTERNATIONAL JOURNAL OF EPIDEMIOLOGIC RESEARCH), 4(2), 166-172. SID. https://sid.ir/paper/351437/en

Vancouver: Copy

karami eshkaftaki Razieh, AHMADINEJAD FERESHTEH, AGHAEI SHAHRZAD, Moghim Hassan, HASHEMZADEH CHALESHTORI MORTEZA, Jami Mohammad Saeid. HEARING LOSS: A REVIEW ON MOLECULAR GENETICS AND EPIDEMIOLOGIC ASPECTS. EPIDEMIOLOGY AND HEALTH SYSTEM JOURNAL (INTERNATIONAL JOURNAL OF EPIDEMIOLOGIC RESEARCH)[Internet]. 2017;4(2):166-172. Available from: https://sid.ir/paper/351437/en

IEEE: Copy

Razieh karami eshkaftaki, FERESHTEH AHMADINEJAD, SHAHRZAD AGHAEI, Hassan Moghim, MORTEZA HASHEMZADEH CHALESHTORI, and Mohammad Saeid Jami, “HEARING LOSS: A REVIEW ON MOLECULAR GENETICS AND EPIDEMIOLOGIC ASPECTS,” EPIDEMIOLOGY AND HEALTH SYSTEM JOURNAL (INTERNATIONAL JOURNAL OF EPIDEMIOLOGIC RESEARCH), vol. 4, no. 2, pp. 166–172, 2017, [Online]. Available: https://sid.ir/paper/351437/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops