PREPARATION OF METHOTREXATE LOADED PLGA NANOPARTICLES COATED WITH PVA AND POLOXAMER188

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MADANI FATEMEH; GOODARZI ARASH; HASHEMI MANSOUREH; MUJOKORO BASIL; KHOSRAVANI MASOOD; ADABI MAHDI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: NANOMEDICINE RESEARCH JOURNAL Year:2018 | Volume:3 | Issue:1 Page(s): 19-24

Download Full-Text

View:

236

Download:

148

Cites:

Information Journal Paper

Title

PREPARATION OF METHOTREXATE LOADED PLGA NANOPARTICLES COATED WITH PVA AND POLOXAMER188

Author(s)

Keywords

METHOTREXATE

PLGA

POLOXAMER188

PVA

Abstract

Objective(s): Nanoparticles offer an attractive platform for drug delivery through a wide variety of the body's physiological barriers. Furthermore, modification of nanoparticle surface with moeites such as POLOXAMER188 can enhance their accumulation and localization at disease site. In this work, we investigated the physiochemical effect of a scavenger receptor (SR-BI) interacting moiety coated on the surface of METHOTREXATE (MTX) -loaded PLGA nanoparticles.Methods: METHOTREXATE-loaded PLGA nanoparticles were prepared by a single step nano precipitation technique. The prepared nanoparticles were characterized by dynamic light scattering (DLS) and scanning electron microscopy (SEM) for their size and morphology respectively. In vitro drug encapsulation efficiency (EE) and relative drug loading (DL) of nanoparticles were examined by UV-Vis spectrophotometry.Results: The results showed that the mean diameter of nanoparticles and zeta potential increased when more POLOXAMER188 was added to preparation process. The DL and EE of MTX increased with increase in POLOXAMER188/PVA ratio. In vitro release of MTX from PLGA nanoparticle was extended by increasing POLOXAMER188 in preparation process.Conclusions: MTX loaded PLGA nanoparticle modified with PVA and poloxamer 188 with suitable sizes and physiochemical properties can potentially improve drug delivery.

Cites

No record.

References

No record.

Cite

APA: Copy

MADANI, FATEMEH, GOODARZI, ARASH, HASHEMI, MANSOUREH, MUJOKORO, BASIL, KHOSRAVANI, MASOOD, & ADABI, MAHDI. (2018). PREPARATION OF METHOTREXATE LOADED PLGA NANOPARTICLES COATED WITH PVA AND POLOXAMER188. NANOMEDICINE RESEARCH JOURNAL, 3(1), 19-24. SID. https://sid.ir/paper/352777/en

Vancouver: Copy

MADANI FATEMEH, GOODARZI ARASH, HASHEMI MANSOUREH, MUJOKORO BASIL, KHOSRAVANI MASOOD, ADABI MAHDI. PREPARATION OF METHOTREXATE LOADED PLGA NANOPARTICLES COATED WITH PVA AND POLOXAMER188. NANOMEDICINE RESEARCH JOURNAL[Internet]. 2018;3(1):19-24. Available from: https://sid.ir/paper/352777/en

IEEE: Copy

FATEMEH MADANI, ARASH GOODARZI, MANSOUREH HASHEMI, BASIL MUJOKORO, MASOOD KHOSRAVANI, and MAHDI ADABI, “PREPARATION OF METHOTREXATE LOADED PLGA NANOPARTICLES COATED WITH PVA AND POLOXAMER188,” NANOMEDICINE RESEARCH JOURNAL, vol. 3, no. 1, pp. 19–24, 2018, [Online]. Available: https://sid.ir/paper/352777/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops