The Association Between Low Levels of Serum Vitamin D and the Duration and Severity of Parkinson’ s Disease

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AHMADI AHANGAR ALIJAN; Saadat Payam; Hajian Karimolah; Kiapasha Gaffar

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Journal: Archives of Neuroscience Year:2018 | Volume:5 | Issue:3 Page(s): 0-0

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Information Journal Paper

Title

The Association Between Low Levels of Serum Vitamin D and the Duration and Severity of Parkinson’ s Disease

Author(s)

AHMADI AHANGAR ALIJAN | Saadat Payam | Hajian Karimolah | Kiapasha Gaffar | Issue Writer Certificate

Keywords

Serum Vitamin D Levels

Parkinson’s Disease

Disease Severity

Duration of the Disease

Cardinal Features

Abstract

Background: Parkinson’ s disease is a neurodegenerative disorder more commonly seen in people aged over 50 years old. The etiology of the disease is unknown, yet the impact of factors, such as vitamin D as a hormone on Parkinson’ s disease has been demonstrated in previous studies. Objectives: The aim of the current study was to investigate the role of low levels of this factor on the severity and Duration of the Disease. Methods: In 2015 to 2016, the current researchers conducted this case-control study on 50 patients with Parkinson’ s disease and 50 healthy subjects as the control group in Babol, Iran. Demographic information (age, gender, and education), serum levels of vitamin D in the two groups, disease duration, Disease Severity, and Cardinal Features of the disease in the patient group were investigated. Data were analyzed using the SPSS 23 software with the t-test, KruskalWallis, Mann-Whitney, and adjusted logistic regression. Results: Themeanserum vitaminDlevels was 27. 28 27. 75 (ng/mL) and 32. 00 17. 76 (ng/mL) in patient and control groups, respectively (P = 0. 009). In terms of the Duration of the Disease, 34 (68%) patients had the disease for less than five years, nine (18%) for five to ten years and seven (14%) for more than ten years. The duration was significantly higher in females (P = 0. 001). Logistic regression analysis with adjusted demographic variables showed that the observed lower levels of serum vitamin D in cases compared with the control group was statistically significant (OR = 4. 17; 95% CI: 1. 37, 12. 71; P = 0. 012). Conclusions: There was a significant relationship between low Serum Vitamin D Levels and the duration and severity of Parkinson’ s disease in patients under 60 years of age.

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Comparison of the calcium-related factors in Parkinson’ s disease patients with healthy individuals

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APA: Copy

AHMADI AHANGAR, ALIJAN, Saadat, Payam, Hajian, Karimolah, & Kiapasha, Gaffar. (2018). The Association Between Low Levels of Serum Vitamin D and the Duration and Severity of Parkinson’ s Disease. ARCHIVES OF NEUROSCIENCE, 5(3), 0-0. SID. https://sid.ir/paper/354689/en

Vancouver: Copy

AHMADI AHANGAR ALIJAN, Saadat Payam, Hajian Karimolah, Kiapasha Gaffar. The Association Between Low Levels of Serum Vitamin D and the Duration and Severity of Parkinson’ s Disease. ARCHIVES OF NEUROSCIENCE[Internet]. 2018;5(3):0-0. Available from: https://sid.ir/paper/354689/en

IEEE: Copy

ALIJAN AHMADI AHANGAR, Payam Saadat, Karimolah Hajian, and Gaffar Kiapasha, “The Association Between Low Levels of Serum Vitamin D and the Duration and Severity of Parkinson’ s Disease,” ARCHIVES OF NEUROSCIENCE, vol. 5, no. 3, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/354689/en

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