مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Warfarin Resistance and Recurrent Thrombosis in an Iranian Patient

Pages

  91-94

Abstract

 Warfarin resistance was known as subtherapeutic INR (International Normalized Ratio) in spite of normally prescribed doses of warfarin. There are few reports of Warfarin resistance from Iran. In this article, we report a 43-year-old man with a history of deep vein thrombosis who took 10 mg of warfarin and 120 mg of enoxaparin daily. He was presented with new acute deep vein thrombosis while taking anticoagulants. Despite warfarin dose increase to 50 mg, the INR did not achieve the therapeutic level. His genetic testing was negative for VKORC1 mutation but positive for CYP2C9*3, which proposed other underlying mechanisms for his Warfarin resistance. This report added to the cases of Warfarin resistance in Iran and herald more attention to warfarin metabolism and its interaction. Also it calls for checking serum warfarin level and Factor II and Factor X level for better evaluating compliance in patients presented with Warfarin resistance.

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    • Cite

    APA: Copy

    Malekzadeh, Masuod, & PAZOKI, MARZIEH. (2018). Warfarin Resistance and Recurrent Thrombosis in an Iranian Patient. CASE REPORTS IN CLINICAL PRACTICE, 3(3), 91-94. SID. https://sid.ir/paper/354741/en

    Vancouver: Copy

    Malekzadeh Masuod, PAZOKI MARZIEH. Warfarin Resistance and Recurrent Thrombosis in an Iranian Patient. CASE REPORTS IN CLINICAL PRACTICE[Internet]. 2018;3(3):91-94. Available from: https://sid.ir/paper/354741/en

    IEEE: Copy

    Masuod Malekzadeh, and MARZIEH PAZOKI, “Warfarin Resistance and Recurrent Thrombosis in an Iranian Patient,” CASE REPORTS IN CLINICAL PRACTICE, vol. 3, no. 3, pp. 91–94, 2018, [Online]. Available: https://sid.ir/paper/354741/en

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