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Information Journal Paper

Title

Ozone Decreases Biomarkers of Inflamation (C-Reactive Protein and Erytrocyte Sedimentation Rate) and Improves Pain, Function and Quality of Life in Knee Osteoarthrtitis Patients: A Before-and-After Study and Review of the Literature

Pages

  0-0

Abstract

 Objectives: The aim of this study was to evaluate if Ozone is capable of decreasing biomarkers of Inflammation (CRP/ESR) and pain, and to improve function and quality of life in knee osteoarthrtitis (OA) patients. Methods: A prospective quasi experimental (before-and-after study) research was performed to investigate the effect of Ozone therapy protocol. The intervention included 4 sessions (1 session/week) of an intra-articular infiltration of a medical mixture of Oxygen-Ozone (95% to 5%) at 20 ug/mL concentration. Biochemical evaluation (CRP and ESR), pain VAS, and WOMAC scales were evaluated before and after the treatment. Results: Overall, 33 patients were evaluated. Mean age was 68. 18  8. 43 years. Female patients accounted for 75. 7% (n = 25) and male patients corresponded to 24. 3% (n = 8). Female: male ratio was 3: 1. The most frequent radiological KL grade was 2º (n = 22, 66. 7%), followed by 3º (n = 8, 24. 2%), and 4º (n = 3, 9. 1%). Biomarkers of Inflammation decreased significantly. C-reactive protein (CRP) diminished from 0. 33  0. 32 mg/dL to 0. 25  0. 23 mg/dL (P = 0. 0456). Erythrocyte sedimentation rate (ESR) decreased from 15. 06  12. 09 mm/h to 11. 81  8. 32 mm/h (P = 0. 01). Before treatment, pain measured by VAS was 7. 33  1. 31 points and decreased to 2. 84  1. 76 (P < 0. 0001). The WOMAC-pain subscale was 14. 84 2. 77 points and diminished to 5. 96 3. 53 (P < 0. 0001), WOMAC stiffness subscale was 3. 06  1. 95 points and ameliorated to 1. 15  1. 3 (P < 0. 0001), WOMAC-function subscale was 41. 15  12. 58 points and decreased to 22. 3 11. 64 (P < 0. 0001). Conclusions: Ozone is capable of both decreasing pain and stiffness and improving function and quality of life in knee OA patients, yet decreases biomarkers of Inflammation, such as CRP and ESR.

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    APA: Copy

    Fernandez Cuadros, Marcos Edgar, Perez Moro, Olga Susana, Albaladejo Florin, Maria Jesus, & Algarra Lopez, Ruben. (2018). Ozone Decreases Biomarkers of Inflamation (C-Reactive Protein and Erytrocyte Sedimentation Rate) and Improves Pain, Function and Quality of Life in Knee Osteoarthrtitis Patients: A Before-and-After Study and Review of the Literature. MIDDLE EAST JOURNAL OF REHABILITATION AND HEALTH STUDIES, 5(2), 0-0. SID. https://sid.ir/paper/354843/en

    Vancouver: Copy

    Fernandez Cuadros Marcos Edgar, Perez Moro Olga Susana, Albaladejo Florin Maria Jesus, Algarra Lopez Ruben. Ozone Decreases Biomarkers of Inflamation (C-Reactive Protein and Erytrocyte Sedimentation Rate) and Improves Pain, Function and Quality of Life in Knee Osteoarthrtitis Patients: A Before-and-After Study and Review of the Literature. MIDDLE EAST JOURNAL OF REHABILITATION AND HEALTH STUDIES[Internet]. 2018;5(2):0-0. Available from: https://sid.ir/paper/354843/en

    IEEE: Copy

    Marcos Edgar Fernandez Cuadros, Olga Susana Perez Moro, Maria Jesus Albaladejo Florin, and Ruben Algarra Lopez, “Ozone Decreases Biomarkers of Inflamation (C-Reactive Protein and Erytrocyte Sedimentation Rate) and Improves Pain, Function and Quality of Life in Knee Osteoarthrtitis Patients: A Before-and-After Study and Review of the Literature,” MIDDLE EAST JOURNAL OF REHABILITATION AND HEALTH STUDIES, vol. 5, no. 2, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/354843/en

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