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Title

Treatment of erythrasma: A double-blinded randomized controlled trial on the clinical application of clotrimazole and sertaconazole

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Abstract

 Introduction: Topical Clotrimazole and Sertaconazole may be effective in the treatment of Erythrasma, a superficial skin infection developed by a group of aerobic microorganisms. This study aimed to compare the effect of Clotrimazole and Sertaconazole on Erythrasma. Methods: In this double-blinded randomized controlled trial, 40 age-matched patients with confirmed Erythrasma diagnosis were divided into two equal groups; one treated with topical 2% Sertaconazole and the other with topical 1% Clotrimazole. The clinical features of Erythrasma were monitored for two weeks (baseline, day 7, and day 14) and compared. Data were analyzed using SPSS v16 software. Results: On day 7, in Clotrimazole group, reduction in erythema and pigmentation were more prominent in comparison to the Sertaconazole group (P = 0. 02 and P = 0. 005, respectively), but there was no difference considering scaling reduction between groups. On day 14, in terms of erythema reduction, the Clotrimazole group performed better compared to the Sertaconazole group (P = 0. 04). Both groups had a significant reduction in Erythrasma symptoms during their treatment period (P < 0. 001). Conclusions: Regarding the results, both Clotrimazole and Sertaconazole are effective medications for Erythrasma treatment. Still, Clotrimazole has a faster recovery process in comparison to Sertaconazole, but no significant difference is observed in outcomes after two weeks of treatment.

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    APA: Copy

    HERIZCHI GHADIM, HAMIDEH, Hekmatshoar, Sevil, Salman Mohajer, Aida, & Hosseini, Mohammad Salar. (2020). Treatment of erythrasma: A double-blinded randomized controlled trial on the clinical application of clotrimazole and sertaconazole. JOURNAL OF RESEARCH IN CLINICAL MEDICINE, 8(1), 0-0. SID. https://sid.ir/paper/355204/en

    Vancouver: Copy

    HERIZCHI GHADIM HAMIDEH, Hekmatshoar Sevil, Salman Mohajer Aida, Hosseini Mohammad Salar. Treatment of erythrasma: A double-blinded randomized controlled trial on the clinical application of clotrimazole and sertaconazole. JOURNAL OF RESEARCH IN CLINICAL MEDICINE[Internet]. 2020;8(1):0-0. Available from: https://sid.ir/paper/355204/en

    IEEE: Copy

    HAMIDEH HERIZCHI GHADIM, Sevil Hekmatshoar, Aida Salman Mohajer, and Mohammad Salar Hosseini, “Treatment of erythrasma: A double-blinded randomized controlled trial on the clinical application of clotrimazole and sertaconazole,” JOURNAL OF RESEARCH IN CLINICAL MEDICINE, vol. 8, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/355204/en

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