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Title

Destructive effect of digitalis overdose on blood-brain barrier in rats; an experimental study

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Abstract

 Introduction: Cardiac glycosides are widely used in critical cardiac diseases despite their unexplained mechanisms on cardio-respiratory system and other autonomic complications within both intra-uterine and post-natal life. The aim of this study is to investigate if digitalis overdose could cause a result in such complications by a destructive effect on Blood-brain barrier (BBB). Methods: Twenty-five male Sprague Dawley rats weighing 300– 350 g were divided into the following groups: control (n=5), sham (isotonic) (n=5), therapeutic dose (n=5), arrhythmogenic dose (n=5), and lethal dose (n=5). The animals were euthanized and their brains were extracted. The brains were histopathologically and immunohistochemically examined to evaluate BBB morphology in the superior temporal cortex. Results: One animal died because of experimental procedures on the first day. Macroscopic examination of brains revealed brain edema, subarachnoid hemorrhage (SAH), and narrowed cisterns in toxic doses of digitalis-treated animals. Brain histopathological examination of these groups revealed bloody subarachnoid and cisternal spaces, cortical arteriolar vasospasm, neurodegeneration, and even peri-arteriolar neuroglial component fragmentation; these changes induced BBB destruction in the high-dose digitalis-treated animals. Conclusion: Digitalis should not be used with overdoses if the cardio-respiratory arrhythmia is unexpectedly appearing in low doses against the possibility of defected or disrupted BBB.

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    APA: Copy

    Kocak, Mehmet Nuri, Caglar, Ozgur, Destegul, Dilek, Nalci, Kemal Alp, Ozmen, Sevilay, & Aydin, Mehmet Dumlu. (2020). Destructive effect of digitalis overdose on blood-brain barrier in rats; an experimental study. JOURNAL OF RESEARCH IN CLINICAL MEDICINE, 8(1), 0-0. SID. https://sid.ir/paper/355220/en

    Vancouver: Copy

    Kocak Mehmet Nuri, Caglar Ozgur, Destegul Dilek, Nalci Kemal Alp, Ozmen Sevilay, Aydin Mehmet Dumlu. Destructive effect of digitalis overdose on blood-brain barrier in rats; an experimental study. JOURNAL OF RESEARCH IN CLINICAL MEDICINE[Internet]. 2020;8(1):0-0. Available from: https://sid.ir/paper/355220/en

    IEEE: Copy

    Mehmet Nuri Kocak, Ozgur Caglar, Dilek Destegul, Kemal Alp Nalci, Sevilay Ozmen, and Mehmet Dumlu Aydin, “Destructive effect of digitalis overdose on blood-brain barrier in rats; an experimental study,” JOURNAL OF RESEARCH IN CLINICAL MEDICINE, vol. 8, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/355220/en

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