DFNB59 GENE MUTATIONS AND ITS ASSOCIATION WITH DEAFNESS IN SCHOOLCHILDREN IN KOHGILOOYEH & BOYERAHMAD PROVINCE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAHERZADEH GHAHFAROKHI M.; FAROKHI EFAT; SHIRMARDI S.A.A.F.; GHASEMI SORAYA; ABOU ALHASANI MARZIEH; AZADEGAN F.; RAEISI S.; RAEISI MARZIEH; BANITALEBI G.; HASHEMZADEH CHALESHTORI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Armaghane Danesh Year:2010 | Volume:14 | Issue:4 (56) Page(s): 31-38

Download Full-Text

Persian Verion

View:

897

Download:

Cites:

Information Journal Paper

Title

DFNB59 GENE MUTATIONS AND ITS ASSOCIATION WITH DEAFNESS IN SCHOOLCHILDREN IN KOHGILOOYEH & BOYERAHMAD PROVINCE

Author(s)

Keywords

DEAFNESSQ2

DFNB59Q3

PCR-SSCPQ2

HETERODUPLEX ANALYSISQ2

Abstract

Introduction & Objective: Hearing loss is a common disease affecting millions of people worldwide. Hearing loss can be caused due to genetic or environmental factors or even both. The genetic of hearing defect is highly heterogeneous and more than 100 genes are predicted to cause this disorder in humans. A newly identified gene (DFNB59) has been shown to cause DEAFNESS in some populations. Here we report mutation analysis for DFNB59 gene in 88 genetic non-syndromic hearing loss subjects. Materials & Methods: In this descriptive-lab based study which was conducted at the Cellular and Molecular Research Center of Shahrekord University of Medical Sciences, DNA was extracted from the peripheral blood samples using standard phenol chloroform procedure. Mutation analysis for DFNB59 gene was performed using PCR-SSCP/HA protocol. The suspected DFNB59 which was detected as shifted bands on PAGE were then confirmed by direct sequencing strategy. Results: Two DFNB59 polymorphisms including c.793C>G and c.793C>T were detected in 8 and 1 deaf subjects respectively. Conclusion: We conclude that there is no association between DFNB59 mutations and DEAFNESS in the studied patients in the region.

Cites

No record.

References

No record.

Cite

APA: Copy

TAHERZADEH GHAHFAROKHI, M., FAROKHI, EFAT, SHIRMARDI, S.A.A.F., GHASEMI, SORAYA, ABOU ALHASANI, MARZIEH, AZADEGAN, F., RAEISI, S., RAEISI, MARZIEH, BANITALEBI, G., & HASHEMZADEH CHALESHTORI, M.. (2010). DFNB59 GENE MUTATIONS AND ITS ASSOCIATION WITH DEAFNESS IN SCHOOLCHILDREN IN KOHGILOOYEH & BOYERAHMAD PROVINCE. ARMAGHAN DANESH, 14(4 (56)), 31-38. SID. https://sid.ir/paper/355946/en

Vancouver: Copy

TAHERZADEH GHAHFAROKHI M., FAROKHI EFAT, SHIRMARDI S.A.A.F., GHASEMI SORAYA, ABOU ALHASANI MARZIEH, AZADEGAN F., RAEISI S., RAEISI MARZIEH, BANITALEBI G., HASHEMZADEH CHALESHTORI M.. DFNB59 GENE MUTATIONS AND ITS ASSOCIATION WITH DEAFNESS IN SCHOOLCHILDREN IN KOHGILOOYEH & BOYERAHMAD PROVINCE. ARMAGHAN DANESH[Internet]. 2010;14(4 (56)):31-38. Available from: https://sid.ir/paper/355946/en

IEEE: Copy

M. TAHERZADEH GHAHFAROKHI, EFAT FAROKHI, S.A.A.F. SHIRMARDI, SORAYA GHASEMI, MARZIEH ABOU ALHASANI, F. AZADEGAN, S. RAEISI, MARZIEH RAEISI, G. BANITALEBI, and M. HASHEMZADEH CHALESHTORI, “DFNB59 GENE MUTATIONS AND ITS ASSOCIATION WITH DEAFNESS IN SCHOOLCHILDREN IN KOHGILOOYEH & BOYERAHMAD PROVINCE,” ARMAGHAN DANESH, vol. 14, no. 4 (56), pp. 31–38, 2010, [Online]. Available: https://sid.ir/paper/355946/en

Related Journal Papers