DISTRIBUTION OF HEPATITIS C VIRUS GENOTYPE AMONG HCV INFECTED PATIENTS IN GOLESTAN PROVINCE, IRAN

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MORADI A.; SEMNANI SH.; KESHTKAR A.A.; KHODABAKHSHI B.; KAZEMINEJAD V.; MOLANA A.A.; ROSHANDEL GH.; BESHARAT S.

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Journal: GOVARESH JOURNAL Year:2010 | Volume:15 | Issue:1 (70) Page(s): 7-13

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Title

DISTRIBUTION OF HEPATITIS C VIRUS GENOTYPE AMONG HCV INFECTED PATIENTS IN GOLESTAN PROVINCE, IRAN

Author(s)

Keywords

HCVQ3

GENOTYPEQ2

RT-PCRQ3

GOLESTAN PROVINCEQ2

IRANQ2

Abstract

Background: Hepatitis C virus (HCV) is one of the main causative factors of liver disease which can lead to chronic hepatitis C infection in 80% of cases. HCV GENOTYPEs have a special worldwide geographic distribution. The goal of the present study was to detect HCV GENOTYPEs in patients with anti-HCV positive titers in GOLESTAN PROVINCE, IRAN.Materials and Methods: In this cross-sectional study, 95 positive HCV samples as detected by RIBA were evaluated. Viral RNA was extracted with a Roche extraction kit and the Fermentase cDNA kit Random hexamer primers was used for viral genomic cDNA synthesis. PCR was performed on all samples by a general pair of primers. Second-step PCR was done with specific primers, and the results were obtained following electrophoresis in 1.5% agarose gel and ethidium bromide staining in documentation gel.Results: General primer PCR revealed 91 positive samples. Assessment of 77 samples determined that the following GENOTYPEs were present: 1 and 3 [1a (19.5%), 1b (19.5%), 3a (15.6%), 3b (24.7%)], 2a (2.6%), 4 (7.8%). The remaining samples were a mixture of GENOTYPEs 1 and 3 (6.5%).Conclusion: The ingmost prevalent GENOTYPEs found were types 1 and 3 in GOLESTAN PROVINCE. This distribution pattern differed from other areas in IRAN, however GENOTYPE 4 was in accordance with other studies. GENOTYPE 2 was only reported in this study and a study in Tehran. Thus, additional, larger studies of HCV GENOTYPEs should be performed for further analysis of genotypic distribution patterns.

Cites

PREVALENCE OF HEPATITIS C VIRUS GENOTYPES AMONG PATIENTS IN COUNTRIES OF THE EASTERN MEDITERRANEAN REGIONAL OFFICE OF WHO (EMRO): A SYSTEMATIC REVIEW AND META-ANALYSIS

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APA: Copy

MORADI, A., SEMNANI, SH., KESHTKAR, A.A., KHODABAKHSHI, B., KAZEMINEJAD, V., MOLANA, A.A., ROSHANDEL, GH., & BESHARAT, S.. (2010). DISTRIBUTION OF HEPATITIS C VIRUS GENOTYPE AMONG HCV INFECTED PATIENTS IN GOLESTAN PROVINCE, IRAN. GOVARESH JOURNAL, 15(1 (70)), 7-13. SID. https://sid.ir/paper/356549/en

Vancouver: Copy

MORADI A., SEMNANI SH., KESHTKAR A.A., KHODABAKHSHI B., KAZEMINEJAD V., MOLANA A.A., ROSHANDEL GH., BESHARAT S.. DISTRIBUTION OF HEPATITIS C VIRUS GENOTYPE AMONG HCV INFECTED PATIENTS IN GOLESTAN PROVINCE, IRAN. GOVARESH JOURNAL[Internet]. 2010;15(1 (70)):7-13. Available from: https://sid.ir/paper/356549/en

IEEE: Copy

A. MORADI, SH. SEMNANI, A.A. KESHTKAR, B. KHODABAKHSHI, V. KAZEMINEJAD, A.A. MOLANA, GH. ROSHANDEL, and S. BESHARAT, “DISTRIBUTION OF HEPATITIS C VIRUS GENOTYPE AMONG HCV INFECTED PATIENTS IN GOLESTAN PROVINCE, IRAN,” GOVARESH JOURNAL, vol. 15, no. 1 (70), pp. 7–13, 2010, [Online]. Available: https://sid.ir/paper/356549/en

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