DETECTION OF HTLV-1 GENOME IN PRIMARY GASTROINTESTINALLYMPHOMAS: A STUDY ON 22 YEARS (1981- 2003) PATHOLOGY ARCHIVE BIOPSY SPECIMENS IN IMAM REZA HOSPITAL, MASHHAD, IRAN

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MAHMOUDI M.; RASTIN M.; KHOEI A.; FARZADNIA M.

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Journal: Iranian Journal of Basic Medical Sciences Year:2004 | Volume:7 | Issue:3 (23) Page(s): 5-10

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Title

DETECTION OF HTLV-1 GENOME IN PRIMARY GASTROINTESTINALLYMPHOMAS: A STUDY ON 22 YEARS (1981- 2003) PATHOLOGY ARCHIVE BIOPSY SPECIMENS IN IMAM REZA HOSPITAL, MASHHAD, IRAN

Author(s)

MAHMOUDI M. | RASTIN M. | KHOEI A. | FARZADNIA M. | Issue Writer Certificate

Keywords

GASTROINTESTINAL TRACT PRIMARY LYMPHOMAQ4

HTLV-1Q3

PCRQ2

Abstract

Non-Hodgkins lymphoma (NHL) with primary gastrointestinal localization (GI-NHL) represents only 1-4% of the malignant tumors in the gastrointestinal tract. However, the gastrointestinal tract is the most common extranodal site of NHL. The etiology of GI-NHL remains unknown, however, recent studies have shown that infection with viruses like HTLV-1 in the gastrointestinal tract may increase the risk of T cell NHL. The present study was designed to investigate the presence of HTLV-1 genome using PCR on paraffin embedded tissue of primary GI-NHL specimens diagnosed during the period from 1981 to 2003 in the Department of Pathology, Imam Reza Hospital, Mashhad, Iran. The total number of biopsies was 103,573; and 65 cases with primary GI-NHL were found. All these 65 specimens were stained with immunohistochemical markers such as LCA, CD20 and CD3. The presence of HTLV-1 genome was detected in 48 selected patients using tax, LTR, pol and env (GD21) primers.Our results show that male to female distribution was 1.5:1. Most of the patients were in their second) or third decades of life. Eight patients (12.3%) had primary lymphoma in the stomach, 52 (80%) in the small intestine, two (3%) in the large intestine, and three (4.7%) patients had multifocal involvements Eileocecal). According to the Revised European-American Lymphoma (REAL) classification, IPSID lymphoma was the most frequent histologic subtype, comprising 40% of the cases. Sixty-four cases were classified as B cell lymphomas, and one as T-cell lymphoma. Out of 48 specimens which were amplified using PCR, two (4.2%) were positive for HTLV-1. The first case was a 55-year old male with diffuse pleomorphic T cell lymphoma who had a lesion in stomach; and the second case was a 15-month-old female with IPSID lymphoma who had involvement at duodenum.

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APA: Copy

MAHMOUDI, M., RASTIN, M., KHOEI, A., & FARZADNIA, M.. (2004). DETECTION OF HTLV-1 GENOME IN PRIMARY GASTROINTESTINALLYMPHOMAS: A STUDY ON 22 YEARS (1981- 2003) PATHOLOGY ARCHIVE BIOPSY SPECIMENS IN IMAM REZA HOSPITAL, MASHHAD, IRAN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 7(3 (23)), 5-10. SID. https://sid.ir/paper/357065/en

Vancouver: Copy

MAHMOUDI M., RASTIN M., KHOEI A., FARZADNIA M.. DETECTION OF HTLV-1 GENOME IN PRIMARY GASTROINTESTINALLYMPHOMAS: A STUDY ON 22 YEARS (1981- 2003) PATHOLOGY ARCHIVE BIOPSY SPECIMENS IN IMAM REZA HOSPITAL, MASHHAD, IRAN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2004;7(3 (23)):5-10. Available from: https://sid.ir/paper/357065/en

IEEE: Copy

M. MAHMOUDI, M. RASTIN, A. KHOEI, and M. FARZADNIA, “DETECTION OF HTLV-1 GENOME IN PRIMARY GASTROINTESTINALLYMPHOMAS: A STUDY ON 22 YEARS (1981- 2003) PATHOLOGY ARCHIVE BIOPSY SPECIMENS IN IMAM REZA HOSPITAL, MASHHAD, IRAN,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 7, no. 3 (23), pp. 5–10, 2004, [Online]. Available: https://sid.ir/paper/357065/en

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