STUDY OF CHANGES IN CELLULAR SURFACE GLYCOPROTEINS OF ALVEOLAR MACROPHAGES IN FIBROTIC LUNG DISORDERS

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BARKHORDARI A.; MCCLURE J.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2006 | Volume:14 | Issue:1 Page(s): 41-46

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Title

STUDY OF CHANGES IN CELLULAR SURFACE GLYCOPROTEINS OF ALVEOLAR MACROPHAGES IN FIBROTIC LUNG DISORDERS

Author(s)

BARKHORDARI A. | MCCLURE J. | Issue Writer Certificate

Keywords

NORMAL LUNGQ3

OCCUPATIONAL LUNG DISEASESQ3

LECTIN HISTOCHEMISTRYQ2

ALVEOLARQ4

MACROPHAGESQ4

Abstract

Introduction: The respiratory system is both a route of entry and exit for toxins and injurious agents, as well as being a target for chemical substances and pathogens. Therefore, an understanding of the structure and function of the migratory cell populations of pulmonary tissues including ALVEOLAR MACROPHAGES is central in a number of important disease processes. This study aimed to identify and specify the glycotypes of ALVEOLAR MACROPHAGES in fibrotic lung disorders. Methods: Sections of paraffin- embedded tissue from 40 cases in both normal human lung and fibrotic lung disorders were studied by immunohistology and by LECTIN HISTOCHEMISTRY with a panel of 27 biotinylated lectins. Results: The findings of this study showed that ten lectins (AHA, PTL- II, AAA, , LTA, UEA-I, BSA- 1B4, VVA, SBA, DBA, PTL-I) did not bind to the ALVEOLAR MACROPHAGES in any of the cases, whereas 17 lectins (GNA, NPA, HHA, l-PHA, e- PHA, LCA, PSA, Con A, LEA, PAA, s- WGA, ECA, MPA, HPA, WFA, SNA, MAA) bound from moderately to strongly. In contrast, in fibrotic lung disorders some glycans were somewhat more marked or changed. Conclusion: Glycans terminating in β- galactose, terminal Gal β1, 3 GalNAc and subsets of GalNAc also appeared in ALVEOLAR MACROPHAGES of fibrotic lung disorders. L- fucosylated and terminal α-linked galactosyl glycans were also detected in diseases states. Subsets of N- glycans were either changed minimally or not at all.

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APA: Copy

BARKHORDARI, A., & MCCLURE, J.. (2006). STUDY OF CHANGES IN CELLULAR SURFACE GLYCOPROTEINS OF ALVEOLAR MACROPHAGES IN FIBROTIC LUNG DISORDERS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 14(1), 41-46. SID. https://sid.ir/paper/35719/en

Vancouver: Copy

BARKHORDARI A., MCCLURE J.. STUDY OF CHANGES IN CELLULAR SURFACE GLYCOPROTEINS OF ALVEOLAR MACROPHAGES IN FIBROTIC LUNG DISORDERS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;14(1):41-46. Available from: https://sid.ir/paper/35719/en

IEEE: Copy

A. BARKHORDARI, and J. MCCLURE, “STUDY OF CHANGES IN CELLULAR SURFACE GLYCOPROTEINS OF ALVEOLAR MACROPHAGES IN FIBROTIC LUNG DISORDERS,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 1, pp. 41–46, 2006, [Online]. Available: https://sid.ir/paper/35719/en

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