Preparation and evaluation of antibactrial effect of polysaccharide nanocomposite contains curcumin for prevention of dental bacterial biofilm formation

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Jahanizadeh Shabnam; MARJANI AZAM; YAZDIAN FATEMEH; OMIDI MEISAM

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2018 | Volume:26 | Issue:9 Page(s): 806-819

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Title

Preparation and evaluation of antibactrial effect of polysaccharide nanocomposite contains curcumin for prevention of dental bacterial biofilm formation

Author(s)

Jahanizadeh Shabnam | MARJANI AZAM | YAZDIAN FATEMEH | OMIDI MEISAM | Issue Writer Certificate

Keywords

Streptococcus mutansQ1

Polysaccharide nanocompositeQ1

CurcuminQ1

Ionic gelationQ1

Dental cariesQ2

Abstract

Introdution: One of the main reasons of Dental caries is the increase in microbial activity in the oral cavity. Streptococcus mutans (S. mutans) is the main etiological agent in Dental caries. The aim of this study was preparation and evaluation bio-nanocomposite Chitosan CS-St-MMT encapsulated with Curcumin fabricated by precipitation and Ionic gelation method and antimicrobial effect was investigated. Methods: The present study was an experimental one. Physiochemical characteristics and structural characterization of nanocomposite were evaluated by the from the perspective of in vitro efficiency, drug release profile, nanocomposite size, zeta potential, surface morphology and FTIR spectra. Results: The optimal formulation nanocomposites had the average particles size of 35. 9 nm and zeta potential 37. 2 mV and Curcumin entrapment efficiency of 91%. The maximum release of the drug for this Nanosystem was about 80%, indicated the control of release in the presence of montmorillonite compared with the absence of montmorillonite nanocomposite. In FTIR studies, absorption peak was observed for Curcumin, starch, chitosan and montmorillonite in nanocomposites, which indicated the mixing of montmorillonite and Curcumin in nanocomposites. Finally, the antibacterial activity of bio nanocomposite against Streptococcus mutans was assessed. Conclusion: Curcumin-loaded bio nanocomposite hindered the formation of biofilm on dental models very effectively, because of the improvement in the encapsulated Curcumin stability and increased water solubility.

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APA: Copy

Jahanizadeh, Shabnam, MARJANI, AZAM, YAZDIAN, FATEMEH, & OMIDI, MEISAM. (2018). Preparation and evaluation of antibactrial effect of polysaccharide nanocomposite contains curcumin for prevention of dental bacterial biofilm formation. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 26(9 ), 806-819. SID. https://sid.ir/paper/35727/en

Vancouver: Copy

Jahanizadeh Shabnam, MARJANI AZAM, YAZDIAN FATEMEH, OMIDI MEISAM. Preparation and evaluation of antibactrial effect of polysaccharide nanocomposite contains curcumin for prevention of dental bacterial biofilm formation. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(9 ):806-819. Available from: https://sid.ir/paper/35727/en

IEEE: Copy

Shabnam Jahanizadeh, AZAM MARJANI, FATEMEH YAZDIAN, and MEISAM OMIDI, “Preparation and evaluation of antibactrial effect of polysaccharide nanocomposite contains curcumin for prevention of dental bacterial biofilm formation,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 9 , pp. 806–819, 2018, [Online]. Available: https://sid.ir/paper/35727/en

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