THE ROLE OF PARATHYROID HORMONE ON STATURE IN MAJOR BETA-THALASSEMIC PATIENTS

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MOSHTAGHI KASHANIAN GH.R.; AHMADI A.; HAYAT BAKHSH M.M.

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Journal: Journal of Rafsanjan University of Medical Sciences Year:2004 | Volume:3 | Issue:4 Page(s): 258-266

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Title

THE ROLE OF PARATHYROID HORMONE ON STATURE IN MAJOR BETA-THALASSEMIC PATIENTS

Author(s)

MOSHTAGHI KASHANIAN GH.R. | AHMADI A. | HAYAT BAKHSH M.M. | Issue Writer Certificate

Keywords

BETA-THALASSAEMIA MAJORQ3

PARATHYROIDQ4

HORMONE IONIZED CALCIUMQ3

INORGANIC PHOSPHATEQ3

ALKALINE PHOSPHATASEQ4

STATUREQ4

WEIGHTQ3

Abstract

Background: Bone changes are typical complications of thalassaemia major, with unknown pathogenesis. There are only a few studies concerning mineral metabolism and PARATHYROID hormone (PTH) level in the patients whit this disorder, but the number of cases are limited and results are controversial. Since there are many major beta-thalassemic patients in Kerman area, the present study investigated the related factors in bone metabolism of these patients including PTH, ionized calcium, INORGANIC PHOSPHATE, and alkaline phosphates level in patients with different age. Material and Methods: In a cross sectional study, blood samples (5ml) were collected from 200 patients refferiry to the thalassemia clinic for blood transfusion. The patients were divided into five different age groups (≤2, 3-7, 8-12, 13-16 and 17-24 years), and their results were compared with the results obtained from 83 healthy subjects as control group. Furthermore, a questionnaire was filled by a physician for all the patients and the control group, which included height, WEIGHT, and clinical symptoms of calcium deficiency. For comparison of height and WEIGHT, patients were divided into 24 groups according to their age.Results: Analysis of data showed significant decreases (p<0.001) in serum level of PTH and calcium of all the patients, while there were significant increases in the level of the INORGANIC PHOSPHATE of them (p<0.01). Furthermore, alkaline phosphates was increased significantly (p<0.05) only in the children ≤ 2 years, compared with the respective control group, while there were no significant changes among the other age groups. Symptoms of calcium deficiency such as par aesthesia were detected in 28%, muscular spasm in 7%, and seizure in 7.5% of the patients. Statistically, only one year old patients had normal height and WEIGHT, while significant decreases were detected for the other age groups (p< 0.05), which became more predominant in the older patients (p<0.001). Conclusion: The present study indicated that the lower secretion of PTH following the deposition of iron in different tissues (89.5% of the patients had ferritin level of above 1500 ng/ml, and 91% had no regular desfral use), that causes the reduction of ionized calcium, and increase of INORGANIC PHOSPHATE. Furthermore, Low level of PTH leads to impaired metabolism of calcium and phosphate, and lower STATURE and body WEIGHT of these patients.

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APA: Copy

MOSHTAGHI KASHANIAN, GH.R., AHMADI, A., & HAYAT BAKHSH, M.M.. (2004). THE ROLE OF PARATHYROID HORMONE ON STATURE IN MAJOR BETA-THALASSEMIC PATIENTS. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 3(4), 258-266. SID. https://sid.ir/paper/357690/en

Vancouver: Copy

MOSHTAGHI KASHANIAN GH.R., AHMADI A., HAYAT BAKHSH M.M.. THE ROLE OF PARATHYROID HORMONE ON STATURE IN MAJOR BETA-THALASSEMIC PATIENTS. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2004;3(4):258-266. Available from: https://sid.ir/paper/357690/en

IEEE: Copy

GH.R. MOSHTAGHI KASHANIAN, A. AHMADI, and M.M. HAYAT BAKHSH, “THE ROLE OF PARATHYROID HORMONE ON STATURE IN MAJOR BETA-THALASSEMIC PATIENTS,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 3, no. 4, pp. 258–266, 2004, [Online]. Available: https://sid.ir/paper/357690/en

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