Study of the effect of Panax ginseng extract on histomorphometric changes on cerebrum and cerebellum in 14 days offsprings rat from diabetic mothers

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KARAMI AZAM; Zabihollah Khaksar

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2018 | Volume:26 | Issue:2 Page(s): 164-176

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Title

Study of the effect of Panax ginseng extract on histomorphometric changes on cerebrum and cerebellum in 14 days offsprings rat from diabetic mothers

Author(s)

KARAMI AZAM | Zabihollah Khaksar | Issue Writer Certificate

Keywords

Diabetes mellitusQ3

CerebrumQ1

CerebellumQ2

Panax ginseng extractQ1

StreptozotocinQ2

RatQ2

OffspringQ3

Abstract

Introdution: Gestational diabetes induces developmental disorders in different parts of central nervous system and can change dimensions. Ginseng has been used for many years to control diabetes. This study investigated the effect of extract of Panax ginseng on histomorphometric changes on Cerebrum and Cerebellum in Offsprings Rat from diabetic mothers. Methods: 16 Rats were divided into four groups: non-diabetic control, non-diabetic recipient of the extract, diabetic control and diabetic recipient of the extract. Diabetes was induced by Streptozotocin in diabetic groups and all 4 groups became pregnant. During the pregnancy, recipient of the extract groups received the extract at the dose of 400 mg/kg of body weight every day. 14 days of normal delivery; Offsprings were anesthetized. The Cerebrum and Cerebellum was removed by cutting the skull. After the using the techniques of histology, some histological factors were measured. Data were analyzed by using SPSS software version 20, ANOVA and Duncan statistical tests (P≤ 0. 05). Results: A significant reduction was observed in thickness and cell count of gray matter of Cerebrum and cell count of white matter of Cerebellum in diabetic control group than non-diabetic groups (P≤ 0. 05). In addition, a significant reduction was observed in cell count of white matter of Cerebrum in diabetic control group than other groups (P≤ 0. 05). Conclusion: Extract of Panax ginseng can control hyperglycemia and reduce disorders on the Cerebrum and Cerebellum in Offsprings of mothers with gestational diabetes by increasing insulin production and reduction of blood sugar.

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APA: Copy

KARAMI, AZAM, & Zabihollah, Khaksar. (2018). Study of the effect of Panax ginseng extract on histomorphometric changes on cerebrum and cerebellum in 14 days offsprings rat from diabetic mothers. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 26(2 ), 164-176. SID. https://sid.ir/paper/35777/en

Vancouver: Copy

KARAMI AZAM, Zabihollah Khaksar. Study of the effect of Panax ginseng extract on histomorphometric changes on cerebrum and cerebellum in 14 days offsprings rat from diabetic mothers. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(2 ):164-176. Available from: https://sid.ir/paper/35777/en

IEEE: Copy

AZAM KARAMI, and Khaksar Zabihollah, “Study of the effect of Panax ginseng extract on histomorphometric changes on cerebrum and cerebellum in 14 days offsprings rat from diabetic mothers,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 2 , pp. 164–176, 2018, [Online]. Available: https://sid.ir/paper/35777/en

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