STUDY OF IMMUNE SYSTEM IN BONE MARROW TRANSPLANTATION IN DR.ALI SHARIATI HOSPITAL DURING THE YEARS 1993-1995

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ABEDIAN S.; GHAVAMZADEH ARDESHIR; BAYBOURDI M.D.; NIKABIN B.

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2002 | Volume:12 | Issue:34 Page(s): 273-31

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Title

STUDY OF IMMUNE SYSTEM IN BONE MARROW TRANSPLANTATION IN DR.ALI SHARIATI HOSPITAL DURING THE YEARS 1993-1995

Author(s)

ABEDIAN S. | GHAVAMZADEH ARDESHIR | BAYBOURDI M.D. | NIKABIN B. | Issue Writer Certificate

Keywords

BONE MARROW TRANSPLANTIONQ3

IMMUNITYQ3

CELLULARQ4

NITROBLUE TETRAZOLIUMQ3

Abstract

Background and purpose: Reconstitution and function of immune system following bone marrow transplantation in order to treat hematologic malignancy, aplastic anemia and/or immune system disorders is accompanied by changes and complications, hence the purpose of this research is to evaluate immune system function in transplanted pateints.Materials and methods: Study of immune system function was determined by L.T.T.test, NBT reduction and assessment of CD19, CD20, CD2, CD3, CD4, CD8 and CD 56 indices by monoclonal antibody for qualitative and quantitative evaluation of immune system.Results: Number of 36 (18 women and 18 men) patients with age range of 4 to 74 years were under investigation, the immune system at the first trimester after any transplantation and pressence of undergoing disease declined. But then after the number of immune cells and the function increased. Test of phagocytosis at first trimester after transplantation and following it, is normal.CD 56 killer cells have increased at the first trimester of transplantation, but the ratio of CD4 to CD8 decreased (P<0.05). The number of CD19 and CD20 B cells decreased at the first trimester, then after increased.Conclusion: Immune system reconstitution plays a very important role in prevention of infection and wellbeing of the recipients. It seems that presence of CD5 natural cells have a major role in immune surveillance soon after transplantation and also reconstitution of T cells efficiency of defense in PRMI culture has an effective role in surveillance of the individual against diseases.

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APA: Copy

ABEDIAN, S., GHAVAMZADEH, ARDESHIR, BAYBOURDI, M.D., & NIKABIN, B.. (2002). STUDY OF IMMUNE SYSTEM IN BONE MARROW TRANSPLANTATION IN DR.ALI SHARIATI HOSPITAL DURING THE YEARS 1993-1995. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 12(34), 273-31. SID. https://sid.ir/paper/357777/en

Vancouver: Copy

ABEDIAN S., GHAVAMZADEH ARDESHIR, BAYBOURDI M.D., NIKABIN B.. STUDY OF IMMUNE SYSTEM IN BONE MARROW TRANSPLANTATION IN DR.ALI SHARIATI HOSPITAL DURING THE YEARS 1993-1995. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;12(34):273-31. Available from: https://sid.ir/paper/357777/en

IEEE: Copy

S. ABEDIAN, ARDESHIR GHAVAMZADEH, M.D. BAYBOURDI, and B. NIKABIN, “STUDY OF IMMUNE SYSTEM IN BONE MARROW TRANSPLANTATION IN DR.ALI SHARIATI HOSPITAL DURING THE YEARS 1993-1995,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 12, no. 34, pp. 273–31, 2002, [Online]. Available: https://sid.ir/paper/357777/en

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